Biomarker: endoglin

Biomarker subtype: mRNA

Clinical application: prognosis(not significantly altered )

Histology type: endometrial carcinoma

Country: Poland

Region: Lodz

Cohort age: 60 (36–85)

Sample type : tissue

Clinical method: Quantitative Real-Time PCR

Expression pattern : expression

Statictics: Mean ;Range

Cohort age: 60 (36–85)

Description: Correlation of the endoglin level with pronounced cancer malignancy suggests that it may be regarded as a potential prognostic marker of primary endometrial cancer.

Approved symbol: ENG

Approved name: endoglin

Locus type: gene with protein product

HGNC ID: HGNC:3349

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3349

Symbol status: Approved

Previous symbols: ORW1 ORW

Alias symbols: END HHT1 CD105

Alternative gene group name: "cluster of differentiation molecules", "cluster of designation molecules"

OMIM: 131195

Omim link: https://www.omim.org/entry/131195

NCBI name: 2022

NCBI link: https://www.ncbi.nlm.nih.gov/gene/2022

Summary: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Expression: Broad expression in spleen (RPKM 69.2), lung (RPKM 66.7) and 24 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/2022#gene-expression

PDB ID: P17813

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P17813)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

CC term ID: GO:0072563

CC term name: endothelial microparticle

Source description: TF

Term ID: TF:M05924$TF:M06644

Term name: Factor: Znf408; motif: NAGGCCGGGWTT$Factor: ZNF184; motif: NKGTTCAAMGGG