Basic information
Biomarker: CDH1
Biomarker subtype: mRNA
Clinical application: diagnosis
Histology type: endometrial carcinoma
Stage: low grade
Cohort characteristics
Country: Poland
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 83 | EC | 83 |
Sample information
Sample type : tissue
Clinical method: RT-PCR
Expression pattern : expression
Disease information
Related information
Description: CDH1 mRNA expression seems to be an important marker of cancer progression and metastases in endometrial malignant tumors.
Approved symbol: CDH1
Approved name: cadherin 1
Locus type: gene with protein product
HGNC ID: HGNC:1748
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1748
Symbol status: Approved
Previous symbols: UVO
Alternative gene group name: | luster of differentiation molecules", "cluster of designation molecules
Subgroup: Major cadherins (CDH)|
OMIM: 192090
Omim link: https://www.omim.org/entry/192090
NCBI name: 999
NCBI link: https://www.ncbi.nlm.nih.gov/gene/999
Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Expression: Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/999#gene-expression
PDB ID: P12830
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P12830)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: CORUM
Term ID: CORUM:5319| CORUM:5320|CORUM:5281
Term name: CDH1-CKS1B complex| CDH1-SKP2 complex|Cell-cell junction complex (CDH1-CTNNB1)
