Basic information
Biomarker: CGRRF1
Biomarker subtype: mRNA
Clinical application: treatment(metformin respons)
Histology type: endometrial carcinoma
Cohort characteristics
Country: USA
Region: Houston
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 226 | EC | 139 | normal endometrium (NE) | 81 | hyperplasia | 6 |
Sample information
Sample type : tissue
Clinical method: RT-qPCR
Expression elevation: 2-ΔΔCt was calculated and used as an indication of the relative expression levels.
Validation in cell line : ECC-1(American Type Culture Collection, Manassas, VA), Ishikawa (European Collection of Cell Culture), HCT116 p53-/- and p53+/+ (a gift from Dr. Bert Vogelstein, the Ludwig Center at Johns Hopkins)
Validation in cell method : MTT Assay,Immunoblots,Flow cytometric analysis,Western blot.
Validation in animal model : Female Zucker fa/fa obese rats and their lean littermates
Disease information
Related information
Description: CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity.our preliminary data suggests that up-regulation of CGRRF1 expression may prove clinically useful in the prevention or treatment of endometrial cancer.
Approved symbol: CGRRF1
Approved name: cell growth regulator with ring finger domain 1
Locus type: gene with protein product
HGNC ID: HGNC:15528
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15528
Symbol status: Approved
Alias symbols: CGR19 RNF197
Alternative gene group name: zf-RING", "Zinc fingers, RING (C3HC4)-type
Subgroup: Zinc fingers
OMIM: 606138
Omim link: https://www.omim.org/entry/606138
NCBI name: 10668
NCBI link: https://www.ncbi.nlm.nih.gov/gene/10668
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of cell growth. Located in endoplasmic reticulum and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis (RPKM 10.6), thyroid (RPKM 6.6) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/10668#gene-expression
PDB ID: Q99675
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q99675)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
