Basic information
Biomarker: FOXA1
Biomarker subtype: mRNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Norway
Region: Bergen
Study type: prospective study
Followed up time : >60months
Cohort age: 278;251
Protocol age: 118;85
Control age: 160;166
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 194 | primary endometrial adenocarcinoma mRNA | 158 | metastatic endometrial carcinoma mRNA | 42 |
Sample information
Sample type : tissue
Clinical method: Agilent Microarrays (44k) in paralle
Expression pattern : low expression
Disease information
Statictics: cutoff<66;cutoff>66
Cohort age: 278;251
Protocol age: 118;85
Control age: 160;166
Related information
Description: Low FOXA1 is associated with poor survival and suggests a potential for HDAC inhibitors in endometrial carcinoma. A switch in FOXA1 expression from primary to metastatic lesions is observed and gene expression indicates a link between FOXA1 and CDKN2A in metastatic lesions.
Survival figure legend: FOXA1 and survival.$ FOXA1 survival analyses stratified for ERα status in the tumors.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029819/figure/pone-0098069-g001/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029819/figure/pone-0098069-g002/
Approved symbol: FOXA1
Approved name: forkhead box A1
Locus type: gene with protein product
HGNC ID: HGNC:5021
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5021
Symbol status: Approved
Previous symbols: HNF3A
OMIM: 602294
Omim link: https://www.omim.org/entry/602294
NCBI name: 3169
NCBI link: https://www.ncbi.nlm.nih.gov/gene/3169
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 46.5), urinary bladder (RPKM 12.0) and 6 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3169#gene-expression
PDB ID: P55317
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P55317)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
BP term ID: GO:0061144|GO:1902691
BP term name: alveolar secondary septum development|respiratory basal cell differentiation
