Basic information
Biomarker: ZEB1
Biomarker subtype: mRNA
Clinical application: diagnosis(predict the lymph node metastasis)
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Wuhu
Cohort age: 63.9±8.7;47-73
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 452 | EC |
Sample information
Sample type : cytology
Clinical method: RT-PCR
Expression pattern : expression
Disease information
Statictics: Mean (SD);Range
Cohort age: 63.9±8.7;47-73
Related information
Description: ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.
Approved symbol: ZEB1
Approved name: zinc finger E-box binding homeobox 1
Locus type: gene with protein product
HGNC ID: HGNC:11642
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11642
Symbol status: Approved
Previous symbols: TCF8 PPCD3
Alias symbols: BZP ZEB AREB6 NIL-2-A Zfhep Zfhx1a FECD6
Alternative gene group name: |"zf-C2H2", "Cys2His2-like fold containing"
Subgroup: Homeoboxes, Zinc fingers| Zinc fingers
OMIM: 189909
Omim link: https://www.omim.org/entry/189909
NCBI name: 6935
NCBI link: https://www.ncbi.nlm.nih.gov/gene/6935
Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in endometrium (RPKM 12.8), brain (RPKM 12.1) and 23 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/6935#gene-expression
PDB ID: P37275
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P37275)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: WP | TF | HPA
Term ID: WP:WP2943 | TF:M10768_1 | TF:M10769_1| TF:M10775_1| TF:M10777_1 |HPA:0471383
Term name: Hypoxia-mediated EMT and stemness | Factor: HOXB9; motif: GTCGTAAANY; match class: 1 | Factor: HOXB9; motif: GTCGTAAAAN; match class: 1| Factor: hoxd9; motif: GTCGTAAANN; match class: 1| Factor: hoxd9; motif: GTCGTAAAAN; match class: 1 |skin 2; arrector pili muscle cells[High]
