Biomarker: HOMER2

Biomarker subtype: gene

Clinical application: diagnosis(MT-EC(containing endometrioid and serous differentiation))

Histology type: rare type

Country: USA

Region: Los Angeles

Sample type : tissue

Clinical method: Immunohistochemistry,Sample selection and RNA extraction,Gene expression analysis,

Expression pattern : differentially expressed

Description: Novel specifici markers of MT-EC could be of diagnostic utility and could represent novel therapeutic targets in the future.

Expression figure legend: H&E stained sections of USC and EAC region within an MT-EC (Patient 5).

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488511/figure/pone.0130909.g001/

Approved symbol: HOMER2

Approved name: homer scaffold protein 2

Locus type: gene with protein product

HGNC ID: HGNC:17513

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17513

Symbol status: Approved

Alias symbols: CPD Cupidin Vesl-2 HOMER-2B HOMER-2 HOMER-2A DFNA68

Alternative gene group name: Homer scaffolding proteins

OMIM: 604799

Omim link: https://www.omim.org/entry/604799

NCBI name: 9455

NCBI link: https://www.ncbi.nlm.nih.gov/gene/9455

Summary: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

Expression: Broad expression in prostate (RPKM 9.3), pancreas (RPKM 6.8) and 16 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/9455#gene-expression