Basic information
Biomarker: POLE
Biomarker subtype: gene
Clinical application: prognosis(favorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Shijiazhuang
Study type: retrospective study
Followed up time : 5.2 years
Protocol age: 66
Control age: 58
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 406 | EC | 406 |
Sample information
Sample type : tissue
Clinical method: DNA extractions, Targeted Sequencing and PCR
Expression pattern : exonuclease domain mutations (EDM) mutations
Disease information
Statictics: Median
Protocol age: 66
Control age: 58
Related information
Description: POLE EDMs are prognostic markers associated with excellent outcomes for endometrial carcinoma patients. Further investigation is needed to conclusively determine if treatment is necessary for this group of women.
Approved symbol: POLE
Approved name: DNA polymerase epsilon, catalytic subunit
Locus type: gene with protein product
HGNC ID: HGNC:9177
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9177
Symbol status: Approved
Previous symbols: polymerase (DNA directed), epsilon polymerase (DNA) epsilon, catalytic subunit
Alias symbols: POLE1
Alternative gene group name: DNA-directed DNA polymerases", "Polymerases, DNA directed
OMIM: 174762
Omim link: https://www.omim.org/entry/174762
NCBI name: 5426
NCBI link: https://www.ncbi.nlm.nih.gov/gene/5426
Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013] Expression Broad expression in bone marrow (RPKM 12.9), testis (RPKM 10.8) and 24 other tissues
Expression: Broad expression in bone marrow (RPKM 12.9), testis (RPKM 10.8) and 24 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5426#gene-expression
PDB ID: Q07864
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q07864)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: MIRNA
Term ID: MIRNA:hsa-miR-4790-5p
Term name: hsa-miR-4790-5p
