Basic information
Biomarker: MIF
Biomarker subtype: gene
Clinical application: diagnosis
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Harbin
Cohort age: 28;22
Protocol age: 19;16
Control age: 9;6
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 75 | EC | 40 | endometrial hyperplasia | 20 | NE | 15 |
Sample information
Sample type : tissue
Clinical method: RT-qPCR
Expression pattern : overexpresses
Disease information
Statictics: cutoff<60;cutoff>60
Cohort age: 28;22
Protocol age: 19;16
Control age: 9;6
Related information
Description: MIF was correlated with the occurrence and the development of endometrial cancer, and thus can be used for the early diagnosis and prognosis of endometrial cancer. The present study laid the foundation for identifying new treatments for endometrial cancer.
Expression figure legend: Abscissa indicates pathological characteristics, the vertical axis represents gene content.$Reverse transcription quantitative polymerase chain reaction was used to determine the expression of MIF and c-erbB-2 mRNA in NE, endometrial hyperplasia and EC.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838132/figure/f3-mmr-13-05-3828/$https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838132/figure/f2-mmr-13-05-3828/
Approved symbol: MIF
Approved name: macrophage migration inhibitory factor
Locus type: gene with protein product
HGNC ID: HGNC:7097
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7097
Symbol status: Approved
Previous symbols: macrophage migration inhibitory factor (glycosylation-inhibiting factor
Alias symbols: GIF
OMIM: 153620
Omim link: https://www.omim.org/entry/153620
NCBI name: 4282
NCBI link: https://www.ncbi.nlm.nih.gov/gene/4282
Summary: This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Expression: Broad expression in kidney (RPKM 164.4), prostate (RPKM 93.1) and 21 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/4282#gene-expression
PDB ID: P14174
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(P14174)
BP term ID: GO:0061078 | GO:0090323
BP term name: positive regulation of prostaglandin secretion involved in immune response |prostaglandin secretion involved in immune response
Source description: KEGG
Term ID: KEGG:00360
Term name: Phenylalanine metabolism
