Basic information
Biomarker: HSD17B2
Biomarker subtype: mRNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Norway
Region: Hordaland
Followed up time : 9 years(mean, 7 years)
Cohort age: 84;91
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 175 | EC | 175 |
Sample information
Sample type : tissue
Clinical method: mRNA analyses(cDNA microarray.)/immunohistochemistry
Expression pattern : high HSD17B1 and HSD17B2
Expression elevation: Enzyme levels were categorised in quartiles patients , each consisting of equal number of high levels were classified as all patients in the 2nd, 3rd and 4rd)
Disease information
Statictics: cutoff<67;cutoff>67
Cohort age: 84;91
Related information
Description: In conclusion;HSD17B1 is a promising marker to predict EC prognosis.Immunohistochemical detection of this protein in ECs has low sensitivity and should be improved for future clinical applications.
Approved symbol: HSD17B2
Approved name: hydroxysteroid 17-beta dehydrogenase 2
Locus type: gene with protein product
HGNC ID: HGNC:5211
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5211
Symbol status: Approved
Previous symbols: hydroxysteroid (17-beta) dehydrogenase 2
Alias symbols: HSD17 SDR9C2
Alternative gene group name: SDR family
OMIM: 109685
Omim link: https://www.omim.org/entry/109685
NCBI name: 3294
NCBI link: https://www.ncbi.nlm.nih.gov/gene/3294
Summary: Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3294
PDB ID: P37059
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P37059)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
MF term ID: GO:0047006
MF term name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
