Biomarker: AKR1B10

Biomarker subtype: gene

Clinical application: prognosis

Histology type: endometrial carcinoma

Stage: high grade

Country: Slovenia

Region: Ljubljana

Study type: Comparative Study

Clinical method: Quantitative Real-Time PCR

Expression pattern : down-regulated

Description: These data thus reveal the potential of STAR and AKR1B10 as prognostic biomarkers, which calls for further validation at the protein level.

Approved symbol: AKR1B10

Approved name: aldo-keto reductase family 1 member B10

Locus type: gene with protein product

HGNC ID: HGNC:382

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:382

Symbol status: Approved

Previous symbols: AKR1B11

Alias symbols: AKR1B12 ARL-1 HIS ARL1 HSI ALDRLn

OMIM: 604707

Omim link: https://www.omim.org/entry/604707

NCBI name: 57016

NCBI link: https://www.ncbi.nlm.nih.gov/gene/57016

Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

Expression: Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/57016#gene-expression

PDB ID: O60218

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(O60218)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

MF term ID: GO:0045550

MF term name: geranylgeranyl reductase activity

Source description: KEGG

Term ID: KEGG:00790

Term name: Folate biosynthesis