Biomarker: Asparaginase-like protein 1

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Norway

Region: Bergen

Study type: prospectively study

Followed up time : maximum follow up time>60months

Cohort age: 405;377

Protocol age: 341;275

Control age: 64;102

Sample type : tissue

Clinical method: qRT-PCR

Expression pattern : loss expression

Expression elevation: The cut-off for low ASRGL1 was defined as the lower quartile of cases.

Statictics: cutoff<66;cutoff>66

Cohort age: 405;377

Protocol age: 341;275

Control age: 64;102

Description: Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.

Approved symbol: ASRGL1

Approved name: asparaginase and isoaspartyl peptidase 1

Locus type: gene with protein product

HGNC ID: HGNC:16448

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16448

Symbol status: Approved

Alias symbols: FLJ22316 ALP1 ALP

OMIM: 609212

Omim link: https://www.omim.org/entry/609212

NCBI name: 80150

NCBI link: https://www.ncbi.nlm.nih.gov/gene/80150

Summary: Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in testis (RPKM 38.7), kidney (RPKM 13.5) and 10 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/80150#gene-expression

PDB ID: Q7L266

PDB link: https://alphafold.ebi.ac.uk/entry/Q7L266

MF term ID: GO:0004067|GO:0008798

MF term name: asparaginase activity|beta-aspartyl-peptidase activity

BP term ID: GO:0006530| GO:0033345

BP term name: asparagine catabolic process|asparagine catabolic process via L-aspartate