Biomarker: UCHL1

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Janpanese

Region: Gunma

Study type: retrospective

Followed up time : 4 years

Sample type : tissue

Clinical method: qRT-PCR

Expression pattern : high expression

Expression elevation: The staining results were analyzed based on the immunoreactive score using the following 4-step scale: grade 0, no staining; grade 1, <10% tumor cells with weak staining intensity; grade 2, >10% tumor cells with weak to moderate staining intensity; grade 3, 910% tumor cells with strong staining intensity. The final score was designated as low expression or high expression as follows: grade 0 to 2, low expression; grade 3, high expression. All experiments were performed with a positive control (grade 3) and a negative control (grade 0).

Description: High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.

Approved symbol: ENPP2

Approved name: ectonucleotide pyrophosphatase/phosphodiesterase 2

Locus type: gene with protein product

HGNC ID: HGNC:3357

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3357

Symbol status: Approved

Previous symbols: PDNP2

Alias symbols: ATX PD-IALPHA

OMIM: 601060

Omim link: https://www.omim.org/entry/601060

NCBI name: 5168

NCBI link: https://www.ncbi.nlm.nih.gov/gene/5168

Summary: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

Expression: Broad expression in placenta (RPKM 83.1), brain (RPKM 52.1) and 18 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5168#gene-expression

PDB ID: Q13822

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(Q13822)

MF term ID: GO:0047391

MF term name: alkylglycerophosphoethanolamine phosphodiesterase activity