Biomarker: VDAC1

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Poland

Region: Lodz

Followed up time : range, 2-121months

Protocol age: 63.37±11.64

Control age: 59.55±10.17

Sample type : tissue

Clinical method: Quantitative real-time PCR

Expression pattern : expression(≥ median value)

Expression elevation: For MMR proteins, the tumor was considered aberrant if tumor cells showed a complete absence of nuclear staining with positive non-neoplastic internal control; the tumor was considered intact if tumor cells showed nuclear positivity.

Statictics: Mean (SD)

Protocol age: 63.37±11.64

Control age: 59.55±10.17

Description: Our results suggest that increased expression of voltage-dependent anion channels correlates with tumor progression and may serve as a potential prognostic biomarker in endometrial cancer.

Approved symbol: VDAC1

Approved name: voltage dependent anion channel 1

Locus type: gene with protein product

HGNC ID: HGNC:12669

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12669

Symbol status: Approved

Subgroup: Porins

OMIM: 604492

Omim link: https://www.omim.org/entry/604492

NCBI name: 7416

NCBI link: https://www.ncbi.nlm.nih.gov/gene/7416

Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

Expression: Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/7416#gene-expression

PDB ID: P21796

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(P21796)

BP term ID: GO:0110099| GO:1905091

BP term name: negative regulation of calcium import into the mitochondrion|positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization