Biomarker: ZIC1

Biomarker subtype: DNA

Clinical application: diagnosis(non-invasive detection)

Histology type: endometrioid endometrial carcinoma

Country: The Netherlands

Region: Amsterdam

Cohort age: 40-86

Sample type : urine

Clinical method: quantitative methylation specifc PCR (qMSP)

Expression pattern : increased methylation levels

Expression elevation: The correlation between Cq ratios of each DNA methylation marker between paired urine fractions of both patients and controls was assessed using Spearman’s rank correlation. Correlation coefficient r was defined as moderate (r?=?0.40–0.59), strong (r?=?0.60–0.79), or very strong (r?=?0.80–1.00).

Statictics: Range

Cohort age: 40-86

Description: All DNA methylation markers showed increased methylation levels in patients as compared to controls, in all urine fractions. The highest diagnostic potential for endometrial cancer detection in urine was found in full void urine, with area under the receiver operating characteristic curve values ranging from 0.86 to 0.95

Expression figure legend: DNA methylation levels of GHSR, SST, and ZIC1 in full void urine, urine sediment and urine supernatant from healthy female controls and women with endometrial cancer (EC)

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640380/figure/Fig1/

Approved symbol: ZIC1

Approved name: Zic family member 1

Locus type: gene with protein product

HGNC ID: HGNC:12872

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12872

Symbol status: Approved

Previous symbols: Zic family member 1 (odd-paired Drosophila homolog) Zic family member 1 (odd-paired homolog, Drosophila)

Alias symbols: ZIC ZNF201

Alternative gene group name: zf-C2H2", "Cys2His2-like fold containing

Subgroup: "Zinc fingers"

OMIM: 600470

Omim link: https://www.omim.org/entry/600470

NCBI name: 7545

NCBI link: https://www.omim.org/entry/600470

Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

Expression: Biased expression in brain (RPKM 3.1), liver (RPKM 0.5) and 1 other tissue

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/7545#gene-expression