Basic information
Biomarker: CK-20
Biomarker subtype: mRNA
Clinical application: diagnosis
Histology type: endometrial carcinoma
Cohort characteristics
Country: Israel
Region: Kfar Saba
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 20 | EC | 20 |
Sample information
Sample type : tissue
Clinical method: RT-PCR
Expression pattern : expression
Validation in cell line : colon carcinoma line (HT-29)
Validation in cell method : RT-PCR
Disease information
Related information
Description: The results obtained in this study suggest that RT-PCR of CK-20 is more sensitive than traditional histopathologic methods in the diagnosis of MMs in LNs of patients with endometrial cancer. Thus, due to the aforementioned characteristics of CK-20, it may be considered a powerful biomarker in the detection of MMs in LNs of patients with endometrial cancer.
Approved symbol: KRT20
Approved name: KRT20
Locus type: gene with protein product
HGNC ID: HGNC:20412
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20412
Symbol status: Approved
Previous symbols: keratin 20, type I
Alias symbols: CK20 K20 MGC35423
Alternative gene group name: Keratins (acidic)", "Acidic keratins", "Type I keratins", "Type I intermediate filaments", "Type I cytokeratins
Subgroup: Keratins (KRT)
OMIM: 608218
Omim link: https://omim.org/entry/608218
NCBI name: 54474
NCBI link: https://www.ncbi.nlm.nih.gov/gene/54474
Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Expression: Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/54474#gene-expression
PDB ID: P35900
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(P35900)
