Biomarker: DNA aneuploidy

Biomarker subtype: DNA

Clinical application: diagnosis(biological markers for assessing progression to endometrial carcinoma)

Histology type: endometrial carcinoma

Country: Egypt

Region: Cairo

Sample type : tissue

Clinical method: flow cytometry

Expression pattern : DNA aneuploidy

Expression elevation: DNA aneuploidy was defined as any population with a distinct additional peak(s) or the presence of a tetraploid population greater than 15%

Description: Our results indicate that subsets of endometrial hyperplasia are biologically different as evidenced by the presence of DNA aneuploidy, which may provide biological markerfor assessing progression to endometrial carcinoma.

Detailed Description: Ploidy is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Sets of chromosomes refer to the number of maternal and paternal chromosome copies, respectively, in each homologous chromosome pair, which chromosomes naturally exist as. Somatic cells, tissues, and individual organisms can be described according to the number of sets of chromosomes present (the "ploidy level"): monoploid (1 set), diploid (2 sets), triploid (3 sets), tetraploid (4 sets), pentaploid (5 sets), hexaploid (6 sets), heptaploid[doi:10.1007/bf00119108] or septaploid[3] (7 sets), etc. The generic term polyploid is often used to describe cells with three or more chromosome sets.[doi:10.1007/978-3-642-96327-8][Darlington, C. D. (Cyril Dean) (1937). Recent advances in cytology. Philadelphia: P. Blakiston's son & co. p. 60.]