Basic information
Biomarker: TRPV2
Biomarker subtype: mRNA
Clinical application: prognosis(recurrence)
Histology type: endometrial carcinoma
Stage: high risk
Cohort characteristics
Country: Belgium
Region: UZ Gasthuisberg
Followed up time : 36 months,median
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 54 | EEC+ESC | 54 |
Sample information
Sample type : tissue
Clinical method: RT-qPCR/intracellular Ca2+ imaging
Expression pattern : expression
Validation in cell line : primary endometrial cancer cell cultures (EM018a, EM033, EM012 and EM046)
Validation in cell method : RT-qPCR, Calcium microfluorimetry,Immunohistochemistry,western blot (WB)
Disease information
Related information
Description: Altogether, these data suggest TRPV2 gene expression in the primary tumor biopsy as a valuable predictor for disease recurrence.
Survival figure legend: predict recurrence AUC curve
Survival curve link: https://link.springer.com/article/10.1007/s00018-021-04023-1/figures/7
Approved symbol: TRPV2
Approved name: transient receptor potential cation channel subfamily V member 2
Locus type: gene with protein product
HGNC ID: HGNC:18082
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18082
Symbol status: Approved
Previous symbols: transient receptor potential cation channel, subfamily V, member 2
Alias symbols: VRL VRL-1 VRL1
Alternative gene group name: $ANK repeat containing
Subgroup: Voltage-gated ion channels
OMIM: 606676
Omim link: https://www.omim.org/entry/606676
NCBI name: 51393
NCBI link: https://www.ncbi.nlm.nih.gov/gene/51393
Summary: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/51393#gene-expression
PDB ID: Q9Y5S1
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(Q9Y5S1)
Source description: MIRNA
Term ID: MIRNA:hsa-miR-3186-3p
Term name: hsa-miR-3186-3p
