ECbiomarker

Pubmed	Biomarker	P-value	Description
34420090	CTNNB1	p=0.003	exon 3 mutation VS the presence of squamous differentiation
24670463	MMP2	p=0.015	MMP2 over-expression was negatively correlated with tumor differentiation
24067230	Pin1	p<0.05	Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation
21365617	the core pluripotency factor OCT4	p<0.05	The overexpression of OCT4 was found in poorly differentiated samples compared with that in well-differentiated samples
21365617	microRNA-145	p<0.05	miR-145 was expressed in all of the normal and malignant tissues, expression was markedly decreased in the poorly differentiated tumor samples
16575402	CRBP-1	p<0.017	CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G1 vs G2
16575402	CRBP-1	p<0.0004	CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G1 vs G3
16575402	CRBP-1	p<0.0009	CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G2 vs G3
15678850	c-erbB2		The overexpression of c-erbB2 protein in the examed cases was correlated with the clinical status, histological type of the tumour and the differentiation degree
12819391	endoglin (CD105)	p<0.05	There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation
12819391	endoglin (CD105)		There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation
34420090	CTNNB1	p=0.028	exon 3 mutation VS the absence of mucinous differentiation
9421074	cyclin A	p=0.002	Cyclin A was more frequently expressed in poorly differentiated tumors than in well differentiated tumors
9421074	p53	p=0.016	p53 was more frequently expressed in poorly differentiated tumors than in well differentiated tumors
8664123	cathepsin D		The expression and location of desmoplakin I and II and desmoglein were similar, and their expression decreased with loss of differentiation.
35533253	PKN1		Our results suggest that poorly differentiated endometrial tumors possesses higher PKN1 expression at both mRNA and protein levels.
31308756	hsa_circ_0039569	P=0.001	In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation.
28215640	galectin-3	p=0.044	Differentiation was significantly associated with galectin-3 immunoreactivity
27648714	L1CAM		L1CAM positivity was associated with poor differentiation（OR, 6.1）
27079858	clusterin	p=0.036	Positive clusterin immunostaining was found more frequent in well differentiated endometrial carcinomas, showing significant statistical association
26539494	HE4	p<0.05	A statistically significant difference was observed between the highly differentiated group and the poorly differentiated group in HE4 expression
26362938	ANXA2	p<0.05	The positive rate of expression of ANXA2 in the well differentiated group was significantly lower than the poorly differentiated group
26362938	ANXA2	both p<0.05	The high expression rate in moderately and poorly differentiated groups were 70.8 % (17/24) and 79.1 % (34/43), respectively, which were significantly higher than the well differentiation group (23.5 % [4/17];
26362938	HE4	both p<0.05	The high expression rate of HE4 in moderately and poorly differentiated carcinoma was 58.3 % (14/24) and 48.8 % (21/43), respectively, which was significantly higher than well-differentiated cancer (17.6 % [3/17]

34420090

CTNNB1

p=0.003

exon 3 mutation VS the presence of squamous differentiation

24670463

MMP2

p=0.015

MMP2 over-expression was negatively correlated with tumor differentiation

24067230

Pin1

p<0.05

Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation

21365617

the core pluripotency factor OCT4

p<0.05

The overexpression of OCT4 was found in poorly differentiated samples compared with that in well-differentiated samples

21365617

microRNA-145

p<0.05

miR-145 was expressed in all of the normal and malignant tissues, expression was markedly decreased in the poorly differentiated tumor samples

16575402

CRBP-1

p<0.017

CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G1 vs G2

16575402

CRBP-1

p<0.0004

CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G1 vs G3

16575402

CRBP-1

p<0.0009

CRBP-1 immunodetection decreased in less differentiated carcinomas with significant differences G2 vs G3

15678850

c-erbB2

The overexpression of c-erbB2 protein in the examed cases was correlated with the clinical status, histological type of the tumour and the differentiation degree

12819391

endoglin (CD105)

p<0.05

There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation

12819391

endoglin (CD105)

There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation

34420090

CTNNB1

p=0.028

exon 3 mutation VS the absence of mucinous differentiation

9421074

cyclin A

p=0.002

Cyclin A was more frequently expressed in poorly differentiated tumors than in well differentiated tumors

9421074

p53

p=0.016

p53 was more frequently expressed in poorly differentiated tumors than in well differentiated tumors

8664123

cathepsin D

The expression and location of desmoplakin I and II and desmoglein were similar, and their expression decreased with loss of differentiation.

35533253

PKN1

Our results suggest that poorly differentiated endometrial tumors possesses higher PKN1 expression at both mRNA and protein levels.

31308756

hsa_circ_0039569

P=0.001

In the clinicopathological parameters, the expression level of hsa_circ_0039569 was significantly correlated with tumor differentiation.

28215640

galectin-3

p=0.044

Differentiation was significantly associated with galectin-3 immunoreactivity

27648714

L1CAM

L1CAM positivity was associated with poor differentiation（OR, 6.1）

27079858

clusterin

p=0.036

Positive clusterin immunostaining was found more frequent in well differentiated endometrial carcinomas, showing significant statistical association

26539494

HE4

p<0.05

A statistically significant difference was observed between the highly differentiated group and the poorly differentiated group in HE4 expression

26362938

ANXA2

p<0.05

The positive rate of expression of ANXA2 in the well differentiated group was significantly lower than the poorly differentiated group

26362938

ANXA2

both p<0.05

The high expression rate in moderately and poorly differentiated groups were 70.8 % (17/24) and 79.1 % (34/43), respectively, which were significantly higher than the well differentiation group (23.5 % [4/17];

26362938

HE4

both p<0.05

The high expression rate of HE4 in moderately and poorly differentiated carcinoma was 58.3 % (14/24) and 48.8 % (21/43), respectively, which was significantly higher than well-differentiated cancer (17.6 % [3/17]