Genetic
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Environmental
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Behavioral
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Physiological
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Combined
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Welcome to CirRFKB
CirRFKB is a comprehensive, manually curated resource that integrates circadian-related risk factors associated with cancer initiation and progression. By systematically collecting and classifying genetic, environmental, behavioral, physiological, and combined factors, CirRFKB aims to provide a clear and structured view of how circadian disruption influences cancer.
The knowledgebase includes 471 peer-reviewed articles retrieved from PubMed, forming a total of 4,052 curated entries. These are composed of 1,449 single factors and 340 combined factors, classified into genetic, behavioral, environmental, physiological, and combined categories. Based on their reported effects, these factors are further classified as 323 risk factors, 254 protective factors, 291 no-influencing factors, and 921 unclear factors.
Here, researchers, clinicians, and data scientists can explore categorized data, visualize trends, and identify key genetic, behavioral, environmental, and physiological factors that link circadian clock to cancer. CirRFKB aims to accelerate understanding and discovery at the intersection of chronobiology and oncology. CirRFKB provides a structured data model and standardized annotation pipeline, forming a solid foundation for applications such as risk assessment, predictive modeling, and personalized prevention strategies.
