Biomarker name Biomarker type Expression pattern Clinical application Application supplementary PMID
TRPV2 DNA upregulated diagnosis 34936030
PR protein upregulated diagnosis 34418427
HE4 protein upregulated diagnosis 27562869
CA125 protein upregulated diagnosis 27562869
CA724 protein upregulated diagnosis 27562869
CA19-9 protein upregulated diagnosis 27562869
IL-31 protein upregulated diagnosis 27340318
IL-33 protein upregulated diagnosis 27340318
HE-4 protein upregulated diagnosis 27268621
HE-4 protein upregulated diagnosis 27268621
SIX1 protein upregulated diagnosis 27259717
PAX1 protein upregulated diagnosis 27226215
p53 protein upregulated diagnosis 34418427
miR-887-5p RNA upregulated diagnosis 27177284
IFITM1 protein upregulated diagnosis 27124937
clusterin protein upregulated diagnosis 27079858
HE4 protein upregulated diagnosis 27039795
MIF protein upregulated diagnosis 26985869
c-erbB-2 protein upregulated diagnosis 26985869
MIF DNA upregulated diagnosis 26985869
c‑erbB‑2 DNA upregulated diagnosis 26985869
Estrogen receptor-alpha protein upregulated diagnosis 26957478
CA-125 protein upregulated diagnosis 26925634
IMP3 protein upregulated diagnosis 34418427
ZNF154 CpG DNA upregulated diagnosis 26857064
Nup88 protein upregulated diagnosis 26839161
Nup88 protein upregulated diagnosis 26839161
HE-4 protein upregulated diagnosis 26607777
YKL-40 protein upregulated diagnosis 26607777
HE4 protein upregulated diagnosis 26223178
CDKN2A DNA differentially expressed diagnosis 26132201
H19 DNA differentially expressed diagnosis 26132201
HOMER2 DNA differentially expressed diagnosis 26132201
TNNT1 DNA differentially expressed diagnosis 26132201
L1CAM protein upregulated diagnosis 34418427
MTV Image upregulated diagnosis 26045311
LVSI Image upregulated diagnosis 26028082
CA125 protein upregulated diagnosis 25964114
ARID1A protein downgulated diagnosis 25557364
ZEB1 DNA upregulated diagnosis 25544793
Cyclin D1 protein upregulated diagnosis 25511212
Ki67 protein upregulated diagnosis 25511212
RAB8A protein upregulated diagnosis 25477298
HAND2 protein downgulated diagnosis 25473755
HAND2 protein downgulated diagnosis 25473755
PR protein upregulated diagnosis 34418427
miR-27a RNA diagnosis 25329674
p53 protein upregulated diagnosis 25282036
p53 protein upregulated diagnosis 25282036
IMP2 protein upregulated diagnosis 25282036
IMP2 protein upregulated diagnosis 25282036
IMP3 protein upregulated diagnosis 25282036
IMP3 protein upregulated diagnosis 25282036
cyclin E1 protein upregulated diagnosis 25282036
cyclin E1 protein upregulated diagnosis 25282036
HMGA2 protein upregulated diagnosis 25282036
LCOR protein upregulated diagnosis 34410950
HMGA2 protein upregulated diagnosis 25282036
FolR1 protein upregulated diagnosis 25282036
FolR1 protein upregulated diagnosis 25282036
p16 protein upregulated diagnosis 25282036
p16 protein upregulated diagnosis 25282036
PTEN protein upregulated diagnosis 25282036
PTEN protein upregulated diagnosis 25282036
estrogen receptor protein downgulated diagnosis 25282036
estrogen receptor protein downgulated diagnosis 25282036
estrogen receptor protein downgulated diagnosis 25282036
microRNA 21 RNA upregulated diagnosis 34086554
p53 protein upregulated diagnosis 25282036
IgA autoantibody against DLDDLD（dihydrolipoamide dehydrogenase） protein upregulated diagnosis 25202086
KPNA2 protein upregulated diagnosis 24930886
4-OHE2 metabolite upregulated diagnosis 24722971
MMP2 protein upregulated diagnosis 24670463
DJ-1 protein diagnosis 24614826
DJ-1 protein diagnosis 24614826
DJ-1 protein diagnosis 24614826
DJ-1 protein diagnosis 24614826
miR-203 RNA hypermethylation diagnosis 24530564
miRNA 27a RNA upregulated diagnosis 34076790
miR-203 RNA hypermethylation diagnosis 24530564
SPAG9 protein upregulated diagnosis 24460345
CDH1 DNA upregulated diagnosis 24455846
ITGB1 DNA upregulated diagnosis 24455846
VEGF protein upregulated diagnosis 24420153
maspin protein upregulated diagnosis 24346847
maspin protein upregulated diagnosis 24346847
tumor-associated carbohydrate antigen sTn protein diagnosis 24316923
URI protein upregulated diagnosis 24228101
napsin A protein upregulated diagnosis 24145649
miRNA150-5P RNA upregulated diagnosis 34076790
SUVmax Image upregulated diagnosis 24118160
ProExC protein upregulated diagnosis 23719407
API OTHERS upregulated diagnosis 23700142
PTEN protein upregulated diagnosis 23613406
p53 protein upregulated diagnosis 23613406
S38 protein upregulated diagnosis 23538402
hypoxia-inducible factor 1α protein upregulated diagnosis 23372184
TWIST protein upregulated diagnosis 23372184
E-cadherin protein upregulated diagnosis 23372184
Bub1 protein upregulated diagnosis 23334889
RAGE protein upregulated diagnosis 33922995
ER-α36 protein upregulated diagnosis 23257935
HE4 protein upregulated diagnosis 23179397
cyclin D1 protein upregulated diagnosis 22982899
YKL-40 protein upregulated diagnosis 22945838
PKM2 protein upregulated diagnosis 22889453
HSPA5 protein upregulated diagnosis 22889453
PKM2 protein upregulated diagnosis 22889453
HSPA5 protein upregulated diagnosis 22889453
IPO13 protein upregulated diagnosis 22648251
podocalyxin protein upregulated diagnosis 22412054
TET1 protein downgulated diagnosis 34731191
IDO1 protein upregulated diagnosis 33922995
pEzrin protein upregulated diagnosis 22412054
Notch-1 protein upregulated diagnosis 22378079
HMGA2 protein upregulated diagnosis 22250726
SPAG9 DNA upregulated diagnosis 22146769
SPAG9 protein upregulated diagnosis 22146769
MMP-2 protein upregulated diagnosis 22056701
MMP-9  protein upregulated diagnosis 22056701
PCNA protein upregulated diagnosis 22056701
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
miR-142-3p RNA altered expression diagnosis 33896823
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
CA-125 protein upregulated diagnosis 22037740
p16 protein upregulated diagnosis 22027748
SNCG protein upregulated diagnosis 22015044
SUVmax Image upregulated diagnosis 21764107
HE4 protein upregulated diagnosis 21720250
miR-146a-5p RNA altered expression diagnosis 33896823
microRNA-145 RNA upregulated diagnosis 21365617
Nrf2 protein upregulated diagnosis 21228930
Hsa-miR-155 RNA diagnosis 21176560
NLR cell upregulated diagnosis 20570475
NLR cell upregulated diagnosis 20570475
Glut-1 protein upregulated diagnosis 20527231
beta-catenin protein abnormal expression diagnosis 20527231
L1CAM protein upregulated diagnosis 20077528
myocardin protein upregulated diagnosis 19952936
myocardin protein upregulated diagnosis 19952936
miR-151a-5 RNA altered expression diagnosis 33896823
Claudins protein upregulated diagnosis 19795358
DKK1 protein upregulated diagnosis 19424619
TFF3 protein upregulated diagnosis 18682706
TFF3 DNA upregulated diagnosis 18682706
TFF3 protein upregulated diagnosis 18682706
CD10 protein upregulated diagnosis 18565690
HE4 protein diagnosis 18495222
PTEN protein upregulated diagnosis 18431720
beta-catenin protein upregulated diagnosis 18431720
p53 protein upregulated diagnosis 18431720
Plasma-derived exosomal miR-15a-5p RNA upregulated diagnosis 33781255
NDRG1 protein upregulated diagnosis 18377423
PTEN protein downgulated diagnosis 18377423
beta-catenin protein exon 3 diagnosis 18376386
beta-catenin DNA exon 3 diagnosis 18376386
IMP3 protein upregulated diagnosis 18223334
IMP3 protein upregulated diagnosis 18223334
IMP3 protein upregulated diagnosis 18223334
IMP3 protein upregulated diagnosis 18223334
IMP3 protein upregulated diagnosis 18223334
serum p53 antibody (S-p53 Ab) protein upregulated diagnosis 17980190
Plasma-derived exosomal miR-15a-5p RNA upregulated diagnosis 33781255
serum p53 antibody (S-p53 Ab) protein upregulated diagnosis 17980190
IMP3 protein upregulated diagnosis 17885673
IMP3 protein upregulated diagnosis 17885673
p53 protein upregulated diagnosis 17885673
HLDF factor protein Antibodies to the HLDF factor diagnosis 17722590
CA-125 protein upregulated diagnosis 17260229
HIF-1alpha protein upregulated diagnosis 17099695
GLUT1 protein upregulated diagnosis 16892013
GLUT8 protein upregulated diagnosis 16892013
KLK8 protein upregulated diagnosis 16888409
miR-375 RNA downgulated diagnosis 33668431
TADG-14 DNA upregulated diagnosis 16888409
KLK8 DNA upregulated diagnosis 16888409
CRBP-1 protein downgulated diagnosis 16575402
HDAC8 protein upregulated diagnosis 16538051
Haymaker DNA upregulated diagnosis 16495475
CD10 protein upregulated diagnosis 15938828
SMA protein upregulated diagnosis 15938828
cytokeratin protein upregulated diagnosis 15498190
cytokeratin protein upregulated diagnosis 15498190
CA125 protein upregulated diagnosis 15498190
miR-190b RNA downgulated diagnosis 33668431
CA125 protein upregulated diagnosis 15498190
chaperonin 10 protein upregulated diagnosis 15253447
CD171 protein upregulated diagnosis 15225093
p53 protein upregulated diagnosis 15032075
oxytocin receptor protein upregulated diagnosis 14576480
PTEN DNA downgulated diagnosis 12948417
PTEN protein downgulated diagnosis 12948417
Ki-S1 protein upregulated diagnosis 12556100
h-caldesmon protein upregulated diagnosis 12485478
h-caldesmon protein upregulated diagnosis 12485478
CEA protein upregulated diagnosis 33660848
calponin protein upregulated diagnosis 12485478
calponin protein upregulated diagnosis 12485478
CD10 protein upregulated diagnosis 12485478
CD10 protein upregulated diagnosis 12485478
Desmin protein upregulated diagnosis 12485478
Desmin protein upregulated diagnosis 12485478
SMA protein upregulated diagnosis 12485478
SMA protein upregulated diagnosis 12485478
VEGF protein upregulated diagnosis 12479072
CD10 protein diagnosis 11532038
periostin protein upregulated diagnosis 33660848
Id1 protein upregulated diagnosis 11275368
telomerase activity protein diagnosis 11078809
TERT DNA upregulated diagnosis 11078809
CK-20 protein upregulated diagnosis 10985893
metallothioneins protein upregulated diagnosis 10878548
PTEN DNA Altered expression diagnosis 10841828
PTEN protein Altered expression diagnosis 10841828
CK-20 RNA upregulated diagnosis 10831349
PP14 protein upregulated diagnosis 9804252
PP14 protein upregulated diagnosis 9804252
TET1 DNA downgulated diagnosis 34731191
IDO protein upregulated diagnosis 33660848
CK-20 protein upregulated diagnosis 9790796
CK-20 DNA upregulated diagnosis 9790796
CA125 protein upregulated diagnosis 9648586
melatonin protein upregulated diagnosis 9473168
cyclin A protein upregulated diagnosis 9421074
p53 protein upregulated diagnosis 9421074
Calretinin protein upregulated diagnosis 9390137
DNA aneuploidy DNA DNA aneuploidy diagnosis 9167896
SPF DNA upregulated diagnosis 9167896
c-erbB-2 protein upregulated diagnosis 9167896
CEA protein upregulated diagnosis 33660848
desmoplakin I protein upregulated diagnosis 8697392
desmoplakin II protein upregulated diagnosis 8697392
desmoglein protein upregulated diagnosis 8697392
cathepsin D protein upregulated diagnosis 8664123
sIL-2R protein upregulated diagnosis 8317901
OVX1 protein upregulated diagnosis 8137210
AgNOR DNA upregulated diagnosis 8112955
CA 125 protein diagnosis 8008305
CA125 II protein diagnosis 7737582
PP-4 protein diagnosis 1833844
periostin protein upregulated diagnosis 33660848
GHSR DNA increased methylation levels diagnosis 33143739
SST DNA increased methylation levels diagnosis 33143739
ZIC1 DNA increased methylation levels diagnosis 33143739
MCM5 protein upregulated diagnosis 33059604
neopterin metabolite upregulated diagnosis 28383326
4-OHE2 metabolite upregulated diagnosis 24722971
VEGFR2 protein upregulated diagnosis 35241527
two miRNAs (409 and 200c) and 8 CpG sites (4 CpGs at SLC22A18, 3 at HYAL2, and 1 at FUT7) None diagnosis 35284957
2,3-Pyridinedicarboxylic acid metabolite upregulated diagnosis 3651063
Hematommic acid, ethyl ester metabolite upregulated diagnosis 3651063
IDO protein upregulated diagnosis 33660848
Maltitol metabolite upregulated diagnosis 3651063
13(S)-HODE metabolite upregulated diagnosis 3651063
D-Mannitol metabolite upregulated diagnosis 3651063
zinc finger and SCAN domain containing 12 (ZSCAN12) and/or oxytocin (OXT) DNA hypermethylation diagnosis 35323926
CA125 protein upregulated diagnosis 36396713
YTHDF2 protein upregulated diagnosis 35512522
HE4 protein downgulated diagnosis 33528032
SATB2 protein upregulated diagnosis 33459390
p16 protein upregulated diagnosis 33459390
HE4 protein upregulated diagnosis 33436780
HE4 protein diagnosis 33388311
HE4 protein upregulated diagnosis 33388311
IFITM1 protein upregulated diagnosis 34556086
CA125 protein upregulated diagnosis 33388311
C22-ceramides metabolite diagnosis 33360772
C16-ceramide metabolite diagnosis 33360772
hydroxyhexadecenoylcarnitine metabolite diagnosis 33360772
1-methyladenosine metabolite diagnosis 33360772
C22-ceramides metabolite upregulated diagnosis 33360772
C16-ceramide metabolite upregulated diagnosis 33360772
hydroxyhexadecenoylcarnitine metabolite upregulated diagnosis 33360772
1-methyladenosine metabolite upregulated diagnosis 33360772
TWIST1 protein upregulated diagnosis 33235117
CD10 protein upregulated diagnosis 34556086
LGALS3BP protein upregulated diagnosis 33208911
LGALS3BP protein upregulated diagnosis 33208911
HE4 protein upregulated diagnosis 33156532
HE4 protein upregulated diagnosis 33156532
GHSR DNA increased methylation levels diagnosis 33143739
SST DNA increased methylation levels diagnosis 33143739
ZIC1 DNA increased methylation levels diagnosis 33143739
CA72-4 protein upregulated diagnosis 33099933
CA15.3 protein upregulated diagnosis 33099933
MCM5 protein upregulated diagnosis 33059604
SMA protein upregulated diagnosis 34556086
16α-OHE1 -ERα metabolite high-affinity antigen for EC antibodies diagnosis 32761720
HE4 protein diagnosis 32711295
p53 protein upregulated diagnosis 32703491
mesothelin protein upregulated diagnosis 32468249
CA125 protein upregulated diagnosis 32468249
COX-2 protein upregulated diagnosis 32433831
the total amount of microparticles protein upregulated diagnosis 30618036
endothelial (CD144+) protein upregulated diagnosis 30618036
monocytic (CD14+) protein upregulated diagnosis 30618036
IMP3 protein upregulated diagnosis 30614088
h-caldesmon protein upregulated diagnosis 34556086
L1CAM protein upregulated diagnosis 30591489
L1CAM protein upregulated diagnosis 30557309
CA125 protein upregulated diagnosis 30508211
CK19 DNA upregulated diagnosis 30428472
HE4 protein diagnosis 30414437
MACC1 protein diagnosis 29984790
MACC1 protein upregulated diagnosis 29984790
c-Myc protein diagnosis 29984790
c-Myc protein upregulated diagnosis 29984790
neutrophil lymphocyte ratio (NLR) cell upregulated diagnosis 29936727
CTNNB1 DNA CTNNB1 exon 3 mutation diagnosis 34420090
ProGRP protein upregulated diagnosis 29898448
signal intensity (SI) Image upregulated diagnosis 29895385
miR-29b RNA upregulated diagnosis 29848072
DNA integrity index DNA diagnosis 29382392
cancer antigen 15-3 protein upregulated diagnosis 29114696
IFITM1 protein upregulated diagnosis 28700435
GalNAc-T6 protein upregulated diagnosis 28668893
DJ-1 protein upregulated diagnosis 28618925
neopterin metabolite upregulated diagnosis 28383326
DJ-1 protein upregulated diagnosis 28374920
CTNNB1 DNA CTNNB1 exon 3 mutation diagnosis 34420090
p53 protein upregulated diagnosis 28155970
p53 protein upregulated diagnosis 28155970
p16 protein upregulated diagnosis 28155970
p16 protein upregulated diagnosis 28155970
HE4 protein upregulated diagnosis 28098927
NF-YAs protein upregulated diagnosis 27974701
lamin A protein upregulated diagnosis 27974701
S100P protein upregulated diagnosis 27918216
p16 protein upregulated diagnosis 27902476
p16 protein upregulated diagnosis 27902476

Institutes for Systems Genetics, West China Hospital
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