Basic Information

TLR4

Full name: toll like receptor 4

Gene type: protein coding

HGNC ID: HGNC:11850

Gene location: 9q33.1

Gene resources

NCBI: https://www.ncbi.nlm.nih.gov/gene/7099

Alliance of genome: https://www.alliancegenome.org/gene/HGNC:11850

MANE select: https://www.ncbi.nlm.nih.gov/gene/?term=NM_138554.5

Protein resources

UniProt/Swiss-Prot: https://www.uniprot.org/uniprot/O00206

AlphaFold: https://alphafold.ebi.ac.uk/entry/O00206

MEME motif:

Clinical resources

OMIM: https://www.omim.org/entry/603030

dbVar: https://www.ncbi.nlm.nih.gov/dbvar?LinkName=gene_dbvar&from_uid=7099

Pathway resources

KEGG pathway: https://www.genome.jp/pathway/hsa04064+7099

Variant resources

Gene	Disease type	Variant type	NCBI dbSNP	Alleles	Variant location
TLR4	AMD	Missense Variant	rs4986790	A>G / A>T	chr9:117713024 (GRCh38.p13)
TLR4	AMD	Missense Variant	rs4986791	C>T	chr9:117713324 (GRCh38.p13)
TLR4	AMD	2KB Upstream Variant	rs1927914	G>A	chr9:117702447 (GRCh38.p13)
TLR4	AMD	Intron Variant	rs1927907	C>T	chr9:117710486 (GRCh38.p13)