Basic Information

POLR1C

Full name: RNA polymerase I and III subunit C

Gene type: protein coding

HGNC ID: HGNC:20194

Gene location: 6p21.1

Gene resources

NCBI: https://www.ncbi.nlm.nih.gov/gene/9533

Alliance of genome: https://www.alliancegenome.org/gene/HGNC:20194

MANE select: https://www.ncbi.nlm.nih.gov/gene/?term=NM_203290.4

Protein resources

UniProt/Swiss-Prot: https://www.uniprot.org/uniprot/O15160

AlphaFold: https://alphafold.ebi.ac.uk/entry/O15160

MEME motif:

Clinical resources

OMIM: https://www.omim.org/entry/610060

dbVar: https://www.ncbi.nlm.nih.gov/dbvar?LinkName=gene_dbvar&from_uid=9533

Pathway resources

KEGG pathway: https://www.genome.jp/pathway/hsa03020+9533

Variant resources

Gene	Disease type	Variant type	NCBI dbSNP	Alleles	Variant location
POLR1C	AMD Hyperreflective Foci（+）vs（-）	Intron Variant	rs943080	C>A / C>G / C>T	chr6:43858890 (GRCh38.p13)
POLR1C	Dominant analysis-wet AMD	Intron Variant	rs833060	G>C / G>T	chr6:43767412 (GRCh38.p13)
POLR1C	VA improvement after anti-VEGF	Intron Variant	rs699946	A>G	chr6:43764932 (GRCh38.p13)