Subgroup Female Male Age Gene SNP Pvalue PMID
Early AMD 210 203 70 ±4.7 APOE rs429358 1.97E-01 29851526
Early AMD 626 438 75.1±7.7 LOC105373585 rs6721654 5.11E-01 23326517
Drusen HMCN1 rs721153 2.70E-01 17591627
Drusen HMCN1 rs680638 2.70E-01 17591627
Drusen CFH rs1061170 1.40E-01 17591627
Drusen CFH rs1065489 7.10E-01 17591627
Drusen CFH rs800292 7.00E-02 17591627
Drusen HMCN1 rs743137 2.20E-01 17591627
Drusen HMCN1 rs1475113 5.80E-01 17591627
Drusen HMCN1 rs721153 7.00E-02 17591627
Drusen HMCN1 rs680638 2.70E-01 17591627
early AMD 793 835 CFH rs1061170 1.70E-01 23060141
Early AMD 104 105 69.8±9.0 rs17586843 8.17E-01 23326517
early AMD 793 835 C2 rs547154 9.60E-01 23060141
early AMD 793 835 SKIV2L rs438999 9.90E-01 23060141
early AMD 793 835 ARMS2 rs10490923 9.90E-01 23060141
early AMD 793 835 ARMS2 rs10490924 <0.0001 23060141
early AMD 793 835 HTRA1 rs2672598 2.00E-02 23060141
Early AMD 581 427 ESR1 Haplotype 1 (T-A) rs2234693/rs9340799 1.60E-01 17325140
Early AMD 1322 963 ESR1 Haplotype 1 (T-A) rs2234693/rs9340799 1.60E-01 17325140
Early AMD 188 82 74 IL1RL1 rs1041973 5.00E-02 32871771
Early AMD 188 82 74 IL1RL1 rs1041973 9.48E-01 32871771
Early AMD 188 82 74 IL1RL1 rs1041973 8.50E-02 32871771
Early AMD 41 27 59.8±8.0 LOC105377923 rs7750345 3.00E-02 23326517
Early AMD 188 82 74 IL1RL1 rs1041973 5.99E-01 32871771
Early AMD 188 82 74 IL1RL1 rs1041973 4.20E-02 32871771
Early AMD 188 82 74 IL1RL1 rs1041973 2.49E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 4.28E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 2.02E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 2.94E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 2.26E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 5.01E-01 32871771
Early AMD 188 82 74 IL1RAP rs4624606 1.96E-01 32871771
Early AMD 2826 2015 78.60 ± 7.31 VEGFA rs699947 18708255
Early AMD 44 79 66.1±10.0 GLI3 rs2049622 7.79E-01 23326517
Early AMD 2826 2015 78.60 ± 7.31 VEGFA rs1570360 18708255
Early AMD 2826 2015 78.60 ± 7.31 VEGFA rs2010963 18708255
Early AMD 45 88 66.56±7.6 CFH rs1061170 1.00E-04 22936692
Drusen HTRA1 rs11200638 2.58E-01 17904186
Drusen ARMS2/LOC387715 rs10490924 3.37E-01 17904186
Early AMD 119 39 61.6±8.2 ARMS2 rs2736911 7.73E-01 23687431
Early AMD 119 39 61.6±8.2 ARMS2 rs10490924 5.53E-01 23687431
Early AMD 119 39 61.6±8.2 HTRA1/LOC105378525 rs11200638 4.53E-01 23687431
Early AMD 119 39 61.6±8.2 HTRA1 rs2672598 5.11E-01 23687431
Early AMD 119 39 61.6±8.2 CFH rs3753394 8.68E-01 23687431
Early AMD 57 84 64.9±10.6 rs11986011 9.50E-02 23326517
Early AMD 119 39 61.6±8.2 CFH rs800292 6.80E-01 23687431
Early AMD 119 39 61.6±8.2 CFH rs1061170 9.87E-01 23687431
Early AMD 119 39 61.6±8.2 CFH rs2274700 3.72E-01 23687431
Early AMD 119 39 61.6±8.2 CFH rs3753396 6.32E-01 23687431
Early AMD 119 39 61.6±8.2 CFH rs1065489 6.90E-01 23687431
Early AMD CFH rs1061170 1.00E-01 17198853
Early AMD CFH rs1061170 1.00E-01 17198853
Early AMD CFH rs1061170 17198853
Early AMD 98 202 71.88±10.3 AGER rs1800624 1.69E-01 29317590
Early AMD 98 202 71.88±10.3 AGER rs1800625 3.82E-01 29317590
Early AMD 199 200 62.3±5.5 rs6480975 3.00E-03 23326517
Early AMD 217 92 73 CFI rs10033900 1.22E-01 31583032
Early AMD 217 92 73 CFI rs10033900 1.24E-01 31583032
Early AMD 217 92 73 ERCC6 rs3793784 4.00E-03 31583032
Early AMD 217 92 73 ERCC6 rs3793784 2.45E-01 31583032
Early AMD 217 92 73 VEGFA rs833068 1.75E-01 31583032
Early AMD 217 92 73 VEGFA rs833068 2.71E-01 31583032
Early AMD 217 92 73 HTRA1 rs11200638 2.10E-02 31583032
Early AMD 217 92 73 HTRA1 rs11200638 5.00E-03 31583032
Early AMD 217 92 73 SYN3 rs9621532 2.18E-01 31583032
Early AMD 217 92 73 SYN3 rs9621532 2.66E-01 31583032
Early AMD 462 334 72.5±9.0 ARMS2/HTRA1 rs3793917 1.62E-01 23326517
Early AMD 217 92 73 KCTD10 rs56209061 1.00E-03 31583032
Early AMD 217 92 73 KCTD10 rs56209061 <0.001 31583032
Early AMD 61 72 CFH rs1061170 9.00E-04 18784628
Early AMD 61 72 CFH rs1061170 1.00E-04 18784628
Early AMD 233 152 78.0±9 C5 rs1468673 20022638
Early AMD 233 152 78.0±9 C5 rs1468673 20022638
Early AMD 233 152 78.0±9 C5 rs17611 20022638
Early AMD 233 152 78.0±9 C5 rs17611 20022638
Early AMD 233 152 78.0±9 C5 rs2269066 <0.05 20022638
Early AMD 233 152 78.0±9 C5 rs2269066 20022638
Early AMD 162 96 80.0±4.7 rs4293143 7.74E-01 23326517
Early AMD 233 152 78.0±9 C5 rs25681 20022638
Early AMD 233 152 78.0±9 C5 rs25681 20022638
Early AMD 233 152 78.0±9 C5 rs7026551 <0.05 20022638
Early AMD 233 152 78.0±9 C5 rs7026551 20022638
Early AMD 233 152 78.0±9 C5 rs7027797 20022638
Early AMD 233 152 78.0±9 C5 rs7027797 20022638
Early AMD 233 152 78.0±9 C5 rs7037673 20022638
Early AMD 233 152 78.0±9 C5 rs7037673 <0.05 20022638
Early AMD 233 152 78.0±9 C5 rs7040033 20022638
Early AMD 233 152 78.0±9 C5 rs7040033 20022638
Early AMD 626 438 75.1±7.7 TYR rs621313 6.30E-02 23326517
Early AMD 171 83 73±12 RAD51B rs8017304 7.45E-01 31191752
Early AMD 171 83 73±12 RAD51B rs8017304 9.55E-01 31191752
Early AMD 171 83 73±12 RAD51B rs2588809 4.10E-01 31191752
Early AMD 171 83 73±12 RAD51B rs2588809 3.98E-01 31191752
Early AMD 171 83 73±12 rs4351379 2.29E-01 31191752
Early AMD 171 83 73±12 rs4351379 2.22E-01 31191752
Early AMD 171 83 73±12 COL8A1 rs13095226 9.50E-02 31191752
Early AMD 171 83 73±12 COL8A1 rs13095226 5.85E-01 31191752
Early AMD 90 27 61.0±13.7 CFH rs1061170 17003406
Early AMD 90 27 61.0±13.7 CFH rs1061170 17003406
Early AMD 104 105 69.8±9.0 rs9646096 6.04E-01 23326517
Drusen 213 141 68.6±0.27 IGF1R rs2872060 1.20E-01 22058336
Drusen 213 141 68.6±0.27 IGF1R rs2872060 4.70E-02 22058336
Drusen 213 141 68.6±0.27 IGF1R rs2872060 4.50E-02 22058336
Drusen HTRA1 rs11200638 1.40E-03 17426452
Drusen HTRA1 rs11200638 17426452
Early AMD 285 191 75.05± 8.70 C3 rs2230199 <0.05 19168221
Early AMD 60 29 76.50± 7.21 C3 rs2230199 >0.05 19168221
Early AMD 285 191 75.05± 8.70 C3 rs1047286 <0.05 19168221
Early AMD 60 29 76.50± 7.21 C3 rs1047286 >0.05 19168221
Drusen 41 39 68 ± 8.5 CFH rs3753394 9.41E-01 20523265
Early AMD 210 203 70 ±4.7 APOE rs429358 1.00E+00 29851526
Early AMD 41 27 59.8±8.0 rs10406174 3.40E-02 23326517
Drusen 41 39 68 ± 8.5 CFH rs800292 2.21E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1061170 1.50E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs7535263 5.90E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs2274700 6.00E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1410996 8.83E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1329428 6.59E-01 20523265
Drusen CFHR1/CFHR3 7.28E-01 26045838
Drusen C2 rs547154 6.59E-01 26045838
Drusen C2 rs9332739 5.90E-01 26045838
Drusen C3 rs2230199 9.20E-01 26045838
Early AMD 44 79 66.1±10.0 NECTIN2 rs6857 2.32E-01 23326517
Drusen C3 rs1047286 7.70E-01 26045838
Drusen CFB rs641153 1.66E-01 26045838
Drusen CFB rs4151667 4.68E-01 26045838
Early AMD 133 57 66 CYP4F2 rs2108622 6.48E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 5.62E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 5.62E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 7.26E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 4.68E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 4.66E-01 27652291
Early AMD 133 57 66 CYP4F2 rs2108622 9.90E-01 27652291
Early AMD 57 84 64.9±10.6 TOMM40 rs2075650 3.73E-01 23326517
Early AMD 211 97 74±12 SIRT1 rs3818292 2.91E-01 10.3390/life12050753
Early AMD 211 97 74±12 SIRT1 rs3818292 1.83E-01 10.3390/life12050753
Early AMD 211 97 74±12 SIRT1 rs3758391 6.31E-01 10.3390/life12050753
Early AMD 211 97 74±12 SIRT1 rs3758391 3.94E-01 10.3390/life12050753
Early AMD 211 97 74±12 SIRT1 rs7895833 9.05E-01 10.3390/life12050753
Early AMD 211 97 74±12 SIRT1 rs7895833 7.00E-03 10.3390/life12050753
Early AMD 235 104 73±13 VEGFA rs1570360 1.86E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 2.98E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 3.17E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 4.41E-01 10.3390/cells11060996
Drusen 548 401 78.9±4.9 LIPC rs10468017 4.10E-02 21447678
Early AMD 235 104 73±13 VEGFA rs3025033 3.99E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 2.96E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 2.48E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 4.77E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 4.99E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 1.68E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 9.00E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 8.70E-02 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 2.30E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs1570360 3.40E-01 10.3390/cells11060996
Drusen 548 401 78.9±4.9 ABCA1 rs1883025 7.70E-04 21447678
Early AMD 235 104 73±13 VEGFA rs699947 1.32E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 4.92E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 1.70E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 8.80E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 1.80E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs699947 4.50E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 7.51E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 1.81E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 5.00E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 1.80E-01 10.3390/cells11060996
Drusen 548 401 78.9±4.9 CETP rs3764261 4.20E-01 21447678
Early AMD 235 104 73±13 VEGFA rs3025033 9.10E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs3025033 3.00E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 5.09E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 2.31E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 9.20E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 1.20E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 2.40E-01 10.3390/cells11060996
Early AMD 235 104 73±13 VEGFA rs2146323 4.90E-01 10.3390/cells11060996
Early AMD 214 265 76±12 CCR2 rs1799865 7.23E-01 10.3390/life12071038
Early AMD 214 265 76±12 CCR2 rs1799865 5.77E-01 10.3390/life12071038
Drusen 548 401 78.9±4.9 APOE rs429358 5.10E-01 21447678
Early AMD 214 265 76±12 CCL2 rs4586 7.57E-01 10.3390/life12071038
Early AMD 214 265 76±12 CCL2 rs4586 5.89E-01 10.3390/life12071038
Early AMD 214 265 76±12 CCL2 rs1024611 7.80E-02 10.3390/life12071038
Early AMD 214 265 76±12 CCL2 rs1024611 3.20E-02 10.3390/life12071038
Early AMD 214 265 76±12 CCL2 rs2857656 8.70E-02 10.3390/life12071038
Early AMD 214 265 76±12 CCL2 rs2857656 3.70E-02 10.3390/life12071038
Drusen 548 401 78.9±4.9 CFH rs1061170 9.80E-03 21447678
Drusen 548 401 78.9±4.9 ARMS2 rs10490924 6.30E-05 21447678
Drusen 548 401 78.9±4.9 C2 rs9332739 7.40E-02 21447678
Early AMD 210 203 70 ±4.7 APOE rs429358 4.19E-01 29851526
Drusen 548 401 78.9±4.9 C3 rs2230199 5.60E-02 21447678
Drusen 548 401 78.9±4.9 CFB rs641153 6.90E-02 21447678
Drusen 548 401 78.9±4.9 CFI rs10033900 2.10E-01 21447678
Drusen 146 260 70.7±5.4 CFH rs1061170 2.00E-03 24970616
Drusen 146 260 70.7±5.4 ARMS2 rs10490924 8.10E-01 24970616
Drusen 146 260 70.7±5.4 ABCA1 rs1883025 2.50E-01 24970616
Early AMD LIPC rs493258 3.00E-01 24223199
Early AMD LIPC rs10468017 3.30E-01 24223199
Early AMD rs12678919 5.00E-01 24223199
Early AMD ABCA1 rs1883025 8.90E-01 24223199
Early AMD 210 203 70 ±4.7 APOE rs7412 8.19E-01 29851526
Early AMD CETP rs3764261 1.40E-01 24223199
Drusen 122 94 70.3±6.63 SYN3 rs5749482 2.00E-02 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 1.60E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 4.00E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 5.10E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 9.00E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 7.10E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 3.60E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 7.00E-03 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 6.00E-03 25893111
Early AMD 210 203 70 ±4.7 APOE rs7412 6.67E-01 29851526
Drusen 122 94 70.3±6.63 LIPC rs920915 1.40E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 2.00E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 8.00E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 4.30E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 9.10E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 3.60E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 1.00E-03 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 2.00E-02 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 2.80E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 4.80E-01 25893111
Early AMD 210 203 70 ±4.7 APOE rs7412 5.00E-01 29851526
Drusen 122 94 70.3±6.63 C3 rs2230199 8.20E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 7.30E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 9.60E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 3.00E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 4.90E-02 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 3.00E-02 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 1.90E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 7.70E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 7.80E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 8.80E-01 25893111
Early AMD 199 200 62.3±5.5 rs16851585 1.10E-02 23326517
Drusen 122 94 70.3±6.63 CETP rs3764261 8.30E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 4.40E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 2.00E-03 25893111
Early AMD 206 94 72 ±12 LIPC rs10468017 4.00E-02 30399423
Early AMD 206 94 72 ±12 LIPC rs493258 1.40E-02 30399423
Early AMD 206 94 72 ±12 LPL rs126789919 1.39E-01 30399423
Early AMD 206 94 72 ±12 SIRT1 rs12778366 8.19E-01 30399423
Early AMD 206 94 72 ±12 FGFR2 rs2981582 4.60E-02 30399423
Early AMD 206 94 72 ±12 STAT3 rs744166 4.00E-03 30399423
Early AMD 109 53 78.03±0.68 ARMS2 7.00E-02 23302509
Early AMD 462 334 72.5±9.0 CFH rs1329424 2.30E-01 23326517
Early AMD 109 53 78.03±0.68 CFH 5.40E-01 23302509
Drusen CFH rs1061170 2.78E-02 17591627
Drusen CFH rs1065489 5.00E-02 17591627
Drusen CFH rs800292 1.70E-01 17591627
Drusen HMCN1 rs743137 3.40E-02 17591627
Drusen HMCN1 rs1475113 1.30E-01 17591627
Drusen HMCN1 rs721153 1.00E-01 17591627
Drusen HMCN1 rs680638 3.30E-01 17591627
Drusen CFH rs1061170 6.32E-02 17591627
Drusen CFH rs1065489 2.50E-01 17591627
Early AMD 162 96 80.0±4.7 rs1967689 1.49E-01 23326517
Drusen CFH rs800292 1.70E-01 17591627
Drusen HMCN1 rs743137 1.00E-01 17591627
Drusen HMCN1 rs1475113 1.60E-01 17591627
Drusen HMCN1 rs721153 2.10E-01 17591627
Drusen HMCN1 rs680638 3.30E-01 17591627
Drusen CFH rs1061170 <0.00001 17591627
Drusen CFH rs1065489 3.20E-01 17591627
Drusen CFH rs800292 2.00E-02 17591627
Drusen HMCN1 rs743137 2.40E-01 17591627
Drusen HMCN1 rs1475113 8.70E-01 17591627

Institutes for Systems Genetics, West China Hospital
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