Subgroup Female Male Age Gene SNP Pvalue PMID
dAMD 74 60 72.75±9.55 APOE rs429358 2.72E-01 33467888
Drusen 548 401 78.9±4.9 APOE rs429358 5.10E-01 21447678
dAMD 37 40 71.7±5.3 VEGFA rs2146323 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs2146323 25349791
dAMD 37 40 71.7±5.3 VEGFA rs2146323 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs2146323 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs2146323 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs2146323 <0.05 25349791
dAMD 9 7 76 ± 8 STH rs62063857 5.00E-02 32615840
dAMD 79 51 77.7 ± 7.84 MT2A rs28366003 4.40E-04 28635422
dAMD 104 79 75 ± 8 TLR2 rs5743708 5.00E-03 26398587
dAMD 71 132 75 ±8 CFI rs141853578 2.10E-02 29392637
Drusen 548 401 78.9±4.9 CFH rs1061170 9.80E-03 21447678
dAMD 2826 2015 78.60 ± 7.31 VEGFA rs699947 18708255
dAMD 2826 2015 78.60 ± 7.31 VEGFA rs1570360 18708255
dAMD 2826 2015 78.60 ± 7.31 VEGFA rs2010963 18708255
dAMD 108 171 76 ± 8 SMUG1 rs3087404 2.60E-02 28095127
Drusen HTRA1 rs11200638 2.58E-01 17904186
Drusen ARMS2/LOC387715 rs10490924 3.37E-01 17904186
dAMD 69 37 76.65 ±2.32 ROBO1 rs1387665 9.81E-01 21998696
dAMD 37 31 74.44 ±7.99 ROBO1 rs13076006 8.90E-01 21998696
dAMD 207 86 59.53±5.7 ROBO1 rs4513416 6.14E-01 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs9810404 6.70E-01 21998696
Drusen 548 401 78.9±4.9 ARMS2 rs10490924 6.30E-05 21447678
dAMD 37 31 74.44 ±7.99 ROBO1 rs7640053 9.49E-01 21998696
dAMD 207 86 59.53±5.7 ROBO1 rs7615149 7.17E-01 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs7622888 3.86E-01 21998696
dAMD 37 31 74.44 ±7.99 ROBO1 rs4264688 5.47E-01 21998696
dAMD 207 86 59.53±5.7 ROBO1 rs6548621 7.16E-01 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs7622444 6.98E-01 21998696
dAMD 37 31 74.44 ±7.99 ROBO1 rs9832405 4.70E-01 21998696
dAMD 207 86 59.53±5.7 ROBO1 rs7637338 5.63E-01 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs6548625 4.40E-01 21998696
dAMD 37 31 74.44 ±7.99 ROBO1 rs7623809 3.23E-01 21998696
Drusen 548 401 78.9±4.9 C2 rs9332739 7.40E-02 21447678
dAMD 207 86 59.53±5.7 ROBO1 rs4279056 4.21E-01 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs9826366 4.35E-01 21998696
dAMD 37 31 74.44 ±7.99 ROBO1 rs3923526 2.80E-02 21998696
dAMD 207 86 59.53±5.7 ROBO1 rs9309833 1.50E-02 21998696
dAMD 69 37 76.65 ±2.32 ROBO1 rs7629503 5.00E-02 21998696
dAMD 67 34 72.9±9.4 HMOX2 rs1051308 21804464
dAMD 67 34 72.9±9.4 HMOX2 rs1051308 21804464
dAMD 67 34 72.9±9.4 HMOX2 rs1051308 21804464
dAMD 67 34 72.9±9.4 HMOX2 rs1051308 21804464
dAMD 67 34 72.9±9.4 HMOX2 rs1051308 21804464
Drusen 548 401 78.9±4.9 C3 rs2230199 5.60E-02 21447678
dAMD 67 53 75±8 GSTT1 21212706
dAMD 67 53 75±8 GSTM1 21212706
dAMD 67 53 75±8 GSTP1 21212706
dAMD 67 53 75±8 GSTP1 21212706
dAMD 67 53 75±8 GSTP1 21212706
dAMD 35 59 79.5±5.9 CFH rs1061170 1.00E-02 27316788
dAMD 35 59 79.5±5.9 CFH rs1061170 3.04E-01 27316788
dAMD 35 59 79.5±5.9 CFH rs1061170 6.54E-01 27316788
dAMD 35 59 79.5±5.9 CCL2 rs1024611 9.92E-01 27316788
dAMD 35 59 79.5±5.9 CCL2 rs1024611 3.19E-01 27316788
Drusen 548 401 78.9±4.9 CFB rs641153 6.90E-02 21447678
dAMD 35 59 79.5±5.9 CCL2 rs1024611 8.30E-01 27316788
dAMD 82 23 68.29 ± 10.95 OGG1 rs1052133 1.00E-03 22469746
dAMD 82 23 68.29 ± 10.95 OGG1 rs1052133 1.00E-03 22469746
dAMD 82 23 68.29 ± 10.95 OGG1 rs1052133 22469746
dAMD 82 23 68.29 ± 10.95 OGG1 rs1052133 1.00E-02 22469746
dAMD 82 23 68.29 ± 10.95 OGG1 rs1052133 1.00E-02 22469746
dAMD 82 23 68.29 ± 10.95 MUTYH rs3219489 22469746
dAMD 82 23 68.29 ± 10.95 MUTYH rs3219489 22469746
dAMD 82 23 68.29 ± 10.95 MUTYH rs3219489 22469746
dAMD 82 23 68.29 ± 10.95 MUTYH rs3219489 22469746
Drusen 548 401 78.9±4.9 CFI rs10033900 2.10E-01 21447678
dAMD 120 62 71.4 ±10.0 TF rs4481157 <0.05 23089144
dAMD 120 62 71.4 ±10.0 TF rs4481157 <0.05 23089144
dAMD 120 62 71.4 ±10.0 TF rs4481157 23089144
dAMD 120 62 71.4 ±10.0 TF rs4481157 23089144
dAMD 120 62 71.4 ±10.0 TF rs4481157 23089144
dAMD 63 48 71.9±8.6 TGFB2 rs900 4.43E-01 31614353
dAMD 63 48 71.9±8.6 DCC rs714 7.52E-01 31614353
dAMD ACE 6.00E-02 12099691
dAMD 60 76 71.1 ±7.5 CXCL8 rs2227306 6.00E-02 18235016
dAMD 60 76 71.1 ±7.5 CXCL8 rs2227306 5.80E-01 18235016
Drusen 146 260 70.7±5.4 CFH rs1061170 2.00E-03 24970616
dAMD 20 19 81 ± 7 CFB rs4151667 1.76E-01 32762675
dAMD 20 19 81 ± 7 CFB rs4151667 1.89E-01 32762675
dAMD 312 166 78.8±7.9 CXCL8 rs4073 2.40E-01 18310311
dAMD 46 58 71.1±7.5 VEGFA rs2010963 2.30E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs2010963 2.30E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs833061 2.20E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs833061 1.80E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs1413711 8.40E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs1413711 8.20E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs699947 4.30E-01 18378209
Drusen 146 260 70.7±5.4 ARMS2 rs10490924 8.10E-01 24970616
dAMD 46 58 71.1±7.5 VEGFA rs699947 3.60E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs3025039 8.80E-01 18378209
dAMD 46 58 71.1±7.5 VEGFA rs3025039 8.30E-01 18378209
dAMD 39 48 72.13 ± 5.77 CFH rs1061170 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 CFH rs1061170 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 CFH rs1061170 <0.05 24995509
dAMD 39 48 72.13 ± 5.77 CFH rs1061170 <0.05 24995509
dAMD 39 48 72.13 ± 5.77 CFH rs1061170 <0.05 24995509
dAMD 39 48 72.13 ± 5.77 HIF1A rs11549465 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 HIF1A rs11549465 >0.05 24995509
Drusen 146 260 70.7±5.4 ABCA1 rs1883025 2.50E-01 24970616
dAMD 39 48 72.13 ± 5.77 HIF1A rs11549465 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 HIF1A rs11549465 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 SKIV2L rs429608 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 SKIV2L rs429608 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 SKIV2L rs429608 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 SKIV2L rs429608 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 MYRIP rs2679798 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 MYRIP rs2679798 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 MYRIP rs2679798 >0.05 24995509
dAMD 39 48 72.13 ± 5.77 MYRIP rs2679798 >0.05 24995509
dAMD 74 60 72.75±9.55 APOE rs7412 9.42E-01 33467888
Drusen 122 94 70.3±6.63 SYN3 rs5749482 2.00E-02 25893111
dAMD 39 48 72.13 ± 5.77 MYRIP rs2679798 >0.05 24995509
dAMD 296 681 60.1±5.8 CFH rs1061170 <0.001 17210852
dAMD 296 681 60.1±5.8 CFH rs1061170 <0.001 17210852
dAMD 296 681 60.1±5.8 ARMS2/LOC387715 rs10490924 <0.001 17210852
dAMD 296 681 60.1±5.8 ARMS2/LOC387715 rs10490924 <0.001 17210852
Drusen 213 141 68.6±0.27 IGF1R rs2872060 1.20E-01 22058336
Drusen 213 141 68.6±0.27 IGF1R rs2872060 4.70E-02 22058336
Drusen 213 141 68.6±0.27 IGF1R rs2872060 4.50E-02 22058336
Drusen HTRA1 rs11200638 1.40E-03 17426452
Drusen HTRA1 rs11200638 17426452
Drusen 122 94 70.3±6.63 LIPC rs920915 1.60E-01 25893111
dAMD 67 34 74.3 ± 8.7 NQO1 rs1800566 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NQO1 rs1800566 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NQO1 rs1800566 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NOS3 rs1799983 4.60E-02 23276910
dAMD 67 34 74.3 ± 8.7 NOS3 rs1799983 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NOS3 rs1799983 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NFE2L2 rs6726395 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NFE2L2 rs6726395 >0.05 23276910
dAMD 67 34 74.3 ± 8.7 NFE2L2 rs6726395 >0.05 23276910
Drusen 41 39 68 ± 8.5 CFH rs3753394 9.41E-01 20523265
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 4.00E-01 25893111
Drusen 41 39 68 ± 8.5 CFH rs800292 2.21E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1061170 1.50E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs7535263 5.90E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs2274700 6.00E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1410996 8.83E-01 20523265
Drusen 41 39 68 ± 8.5 CFH rs1329428 6.59E-01 20523265
Drusen CFHR1/CFHR3 7.28E-01 26045838
Drusen C2 rs547154 6.59E-01 26045838
Drusen C2 rs9332739 5.90E-01 26045838
Drusen C3 rs2230199 9.20E-01 26045838
Drusen 122 94 70.3±6.63 C3 rs2230199 5.10E-01 25893111
Drusen C3 rs1047286 7.70E-01 26045838
Drusen CFB rs641153 1.66E-01 26045838
Drusen CFB rs4151667 4.68E-01 26045838
dAMD 414 623 77 PON1 rs854560 3.28E-01 20042177
dAMD 414 623 77 PON1 rs854560 3.41E-01 20042177
dAMD 414 623 77 PON1 rs662 3.77E-01 20042177
dAMD 414 623 77 PON1 rs662 1.26E-01 20042177
dAMD 197 92 72.46 ± 8.51 ACO1 rs867469 <0.05 22331484
dAMD 197 92 72.46 ± 8.51 ACO1 rs867469 <0.05 22331484
dAMD 197 92 72.46 ± 8.51 ACO1 rs867469 22331484
Drusen 122 94 70.3±6.63 SKIV2L rs429608 9.00E-01 25893111
dAMD 197 92 72.46 ± 8.51 ACO1 rs867469 22331484
dAMD 197 92 72.46 ± 8.51 ACO1 rs867469 22331484
dAMD 197 92 72.46 ± 8.51 IREB2 rs17483548 22331484
dAMD 197 92 72.46 ± 8.51 IREB2 rs17483548 22331484
dAMD 197 92 72.46 ± 8.51 IREB2 rs17483548 <0.05 22331484
dAMD 197 92 72.46 ± 8.51 IREB2 rs17483548 <0.05 22331484
dAMD 197 92 72.46 ± 8.51 IREB2 rs17483548 <0.05 22331484
dAMD 97 70 72.67 ± 9.55 IL1B rs1143627 5.50E-01 34132166
dAMD 97 70 72.67 ± 9.55 IL1B rs1143627 3.60E-01 34132166
dAMD 97 70 72.67 ± 9.55 IL1B rs1143627 4.80E-01 34132166
Drusen 122 94 70.3±6.63 CETP rs3764261 7.10E-01 25893111
dAMD 97 70 72.67 ± 9.55 IL1B rs1143627 6.00E-01 34132166
Drusen 122 94 70.3±6.63 CFI rs10033900 3.60E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 7.00E-03 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 6.00E-03 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 1.40E-01 25893111
dAMD 34 33 75.4±11.5 C3 rs2230199 6.00E-04 23209669
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 2.00E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 8.00E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 4.30E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 9.10E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 3.60E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 1.00E-03 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 2.00E-02 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 2.80E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 4.80E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 8.20E-01 25893111
dAMD 34 33 75.4±11.5 CFH rs1061170 7.00E-04 23209669
Drusen 122 94 70.3±6.63 SKIV2L rs429608 7.30E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 9.60E-01 25893111
Drusen 122 94 70.3±6.63 CFI rs10033900 3.00E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 4.90E-02 25893111
Drusen 122 94 70.3±6.63 SYN3 rs5749482 3.00E-02 25893111
Drusen 122 94 70.3±6.63 LIPC rs920915 1.90E-01 25893111
Drusen 122 94 70.3±6.63 ARMS2 rs10490924 7.70E-01 25893111
Drusen 122 94 70.3±6.63 C3 rs2230199 7.80E-01 25893111
Drusen 122 94 70.3±6.63 SKIV2L rs429608 8.80E-01 25893111
Drusen 122 94 70.3±6.63 CETP rs3764261 8.30E-01 25893111
dAMD 34 33 75.4±11.5 HTRA1 rs11200638 3.30E-03 23209669
Drusen 122 94 70.3±6.63 CFI rs10033900 4.40E-01 25893111
Drusen 122 94 70.3±6.63 CFH rs12038333 2.00E-03 25893111
dAMD 117 53 73 CFH rs1061170 3.30E-03 31916060
dAMD 117 53 73 ARMS2 rs10490924 1.01E-01 31916060
dAMD 117 53 73 C2 rs9332739 3.43E-01 31916060
dAMD 117 53 73 C2 rs547154 3.50E-03 31916060
dAMD 117 53 73 CFB rs4151667 3.43E-01 31916060
dAMD 117 53 73 CFB rs2072633 5.65E-01 31916060
dAMD 82 93 66±11 ARMS2 rs10490924 1.00E-02 30895599
dAMD 82 93 66±11 SKIV2L rs429608 3.50E-01 30895599
dAMD APOE rs7412 1.20E-02 10.1016/j.sjbs.2020.06.037
dAMD 82 93 66±11 C3 rs2230199 1.00E+00 30895599
dAMD 82 93 66±11 CFH rs1061170 1.80E-01 30895599
dAMD 7 34 73.3±9.2 ARMS2 rs10490924 1.00E-02 21236409
dAMD 7 34 73.3±9.2 LOXL1 rs1048661 2.10E-01 21236409
Drusen CFH rs1061170 2.78E-02 17591627
Drusen CFH rs1065489 5.00E-02 17591627
Drusen CFH rs800292 1.70E-01 17591627
Drusen HMCN1 rs743137 3.40E-02 17591627
Drusen HMCN1 rs1475113 1.30E-01 17591627
Drusen HMCN1 rs721153 1.00E-01 17591627
Drusen 548 401 78.9±4.9 LIPC rs10468017 4.10E-02 21447678
Drusen HMCN1 rs680638 3.30E-01 17591627
Drusen CFH rs1061170 6.32E-02 17591627
Drusen CFH rs1065489 2.50E-01 17591627
Drusen CFH rs800292 1.70E-01 17591627
Drusen HMCN1 rs743137 1.00E-01 17591627
Drusen HMCN1 rs1475113 1.60E-01 17591627
Drusen HMCN1 rs721153 2.10E-01 17591627
Drusen HMCN1 rs680638 3.30E-01 17591627
Drusen CFH rs1061170 <0.00001 17591627
Drusen CFH rs1065489 3.20E-01 17591627
Drusen 548 401 78.9±4.9 ABCA1 rs1883025 7.70E-04 21447678
Drusen CFH rs800292 2.00E-02 17591627
Drusen HMCN1 rs743137 2.40E-01 17591627
Drusen HMCN1 rs1475113 8.70E-01 17591627
Drusen HMCN1 rs721153 2.70E-01 17591627
Drusen HMCN1 rs680638 2.70E-01 17591627
Drusen CFH rs1061170 1.40E-01 17591627
Drusen CFH rs1065489 7.10E-01 17591627
Drusen CFH rs800292 7.00E-02 17591627
Drusen HMCN1 rs743137 2.20E-01 17591627
Drusen HMCN1 rs1475113 5.80E-01 17591627
Drusen 548 401 78.9±4.9 CETP rs3764261 4.20E-01 21447678
Drusen HMCN1 rs721153 7.00E-02 17591627
Drusen HMCN1 rs680638 2.70E-01 17591627
dAMD 1322 963 ESR1 Haplotype 1 (T-A) rs2234693/rs9340799 5.70E-01 17325140
dAMD 581 539 ESR1 Haplotype 1 (T-A) rs2234693/rs9340799 5.70E-01 17325140
dAMD 37 40 71.7±5.3 VEGFA rs1413711 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs1413711 25349791
dAMD 37 40 71.7±5.3 VEGFA rs1413711 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs1413711 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs1413711 <0.05 25349791
dAMD 37 40 71.7±5.3 VEGFA rs1413711 <0.05 25349791

Institutes for Systems Genetics, West China Hospital
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