hsa-miR-34a

ncRNA information

ncRNA name

hsa-miR-34a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

TGF-Ī²/Smad4

Cancer information

Cancer name

Colorectal Carcinoma

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

OXA-induced downregulation of miR-34a and increased drug resistance by activating macroautophagy in CRC cells.

Tissue resource

colorectal cancer tissues

human colorectal cancer cell lines HT29

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Second Affiliated Hospital of Harbin Medical University

the Cell Bank of Chinese Academy of Sciences

Country

China

Continent

Asia