Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-429
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
ZEB1
Cancer name
Epithelial Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
72
Male patients
Not available
Female patients
Not available
Age range and number
38(<=50)+34(>50)
PMID
Description
Overexpression of miR-429 may suppress ZEB1, and may be a potential sensitizer to cisplatin treatment that may have therapeutic implications.
Tissue resource
epithelial ovarian cancer tissues
human epithelial ovarian carcinoma cell lines SKOV3
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Affiliated Tumor Hospital of Guangxi Medical University
the Affiliated Tumor Hospital of Guangxi Medical University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.