CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-100

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ZNRF2

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

28

Male patients

21

Female patients

7

Age range and number

21(<60)+7(>=60)

Research information

PMID

28416774

Description

Our data suggest that re-expression of miR-100 may inhibit OS cell growth and decrease OS cell chemo-resistance.

Tissue resource

paired normal bone tissue and osteosarcoma specimens

human osteosarcoma cell lines U2OS

Experiment

qRT-PCR,Western blot

Institute

the First Affiliated Hospital of Liaoning Medical University

Country

China

Continent

Asia