hsa-miR-199a

ncRNA information

ncRNA name

hsa-miR-199a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

HIF-Ī±

Cancer information

Cancer name

Osteosarcoma

Cancer site

Bone, Articular Cartilage

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Overexpression of miR-199a sensitizes cisplatin resistant osteosarcoma cells through inhibition of HIF-1Ī± in vitro and in vivo.

Tissue resource

osteosarcoma patient samples and their matched adjacent normal tissues

human osteosarcoma cell lines MG-63

human osteosarcoma cell lines U-2OS

human osteosarcoma cell lines SaoS-2

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

First People's Hospital in Kashgar area

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia