Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-199a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
HIF-Ī±
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Overexpression of miR-199a sensitizes cisplatin resistant osteosarcoma cells through inhibition of HIF-1Ī± in vitro and in vivo.
Tissue resource
osteosarcoma patient samples and their matched adjacent normal tissues
human osteosarcoma cell lines MG-63
human osteosarcoma cell lines U-2OS
human osteosarcoma cell lines SaoS-2
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
First People's Hospital in Kashgar area
American Type Culture Collection
Country
China
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.