Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-340-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
LPAATĪ²
Cancer name
Osteosarcoma
Cancer site
Bone, Articular Cartilage
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our data indicated that miR-340-5p enhanced the sensitivity to CDDP by targeting LPAATĪ².
Tissue resource
osteosarcoma cell lines MG-63
osteosarcoma cell lines Saos-2
osteosarcoma cisplatin-resistant cell lines MG-63/CDDP
osteosarcoma cisplatin-resistant cell lines Saos-2/CDDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Shanghai Cell Institute
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.