Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
lncARSR
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Prognosis
Upstream regulatory factors
Not available
Downstream target
PTEN-PI3K/Akt signaling pathway
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our results showed that upregulated lncARSR promotes doxorubicin resistance in HCC via modulating PTEN-PI3K/Akt pathway, and implied that lncARSR may serve as a promising prognostic biomarker and therapeutic target for HCC chemo-resistance.
Tissue resource
hepatocellular carcinoma tissues and adjacent noncancerous liver tissues
human hepatocellular carcinoma cell lines SMMC-7721
human hepatocellular carcinoma cell lines HepG2
Experiment
qRT-PCR,Western blot
Institute
The Affiliated Hospital of Southwest Medical University
Shanghai Institute of Cell Biology, Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.