Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-200c
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ZEB2
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
50
Male patients
28
Female patients
22
Age range and number
Not available
PMID
Description
Upregulation of miR-200c or downregulation of ZEB2 enhanced the sensitivity of SGC7901/DDP cells to DDP.
Tissue resource
gastric cancer tissues and paired normal adjacent tissues
human gastric cancer cell lines SGC7901
human gastric cancer cisplatin-resistant cell lines SGC7901/DDP
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
the First Affiliated Hospital of Henan University of Science and Technology
the Cell Bank of the Chinese Academy of Sciences
the KeyGen Biotech Co., Ltd.
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.