Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-124
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Acute Lymphoblastic Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Glucocorticoid
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-124 contributes to glucocorticoid resistance in acute lymphoblastic leukemia.
Tissue resource
blood from prednisone-good response acute lymphoblastic leukemia and prednisone-poor response acute lymphoblastic leukemia
human acute lymphoblastic leukemia prednisone-sensitive cell lines CCRF-CEM
human acute lymphoblastic leukemia prednisone-resistant cell lines Jurkat
human acute lymphoblastic leukemia prednisone-resistant cell lines CEM/C1
Experiment
qRT-PCR,Western blot
Institute
the First Affiliated Hospital of Sun Yat-sen University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.