Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
TIMP3
Cancer name
Oral Squamous Cell Carcinoma
Cancer site
Lip, Oral Cavity
Treatment type
Chemotherapy
Drug
Doxorubicin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
These results indicated that OSCC cells are resistant to doxorubicin through upregulation of miR-221.
Tissue resource
oral squamous cell carcinoma cell lines SCC4
oral squamous cell carcinoma cell lines SCC9
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Beijing Institute for Cancer Research
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.