Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-21
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Renal Carcinoma
Cancer site
Kidney
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Dovitinib/Oxaliplatin/Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
99
Male patients
63
Female patients
26
Age range and number
45(<60)+44(>60)
PMID
Description
MiR-21 silencing significantly increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib.
Tissue resource
primary colorectal cancer samples
human proximal tubule epithelial cell lines HK-2
human renal cancer cell lines ACHN
human renal cancer cell lines 786-O
human renal cancer cell lines RCC4
Experiment
qRT-PCR,Western blot
Institute
Tumor Bank and Tissue Collection of the Department of pathology of Lille Hospital
American Type Culture Collection
Country
France
USA
Continent
Asia
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.