PCAT-1

ncRNA information

ncRNA name

PCAT-1

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

c-Myc

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

The results showed that knockdown of PCAT-1 in CRC cells suppressed cell motility and invasiveness, and sensitized the cells to 5-fluorouracil.

Tissue resource

colorectal cancer specimens and the corresponding para-carcinoma tissues

human colorectal cancer cell lines Caco-2

human colorectal cancer cell lines HT-29

Experiment

qRT-PCR,Western blot


Institute

The First Hospital of China Medical University

the Cell Bank of Chinese Academy of Sciences

Country

China

Continent

Asia