Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTAIR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-218
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
152
Male patients
105
Female patients
47
Age range and number
Not available
PMID
Description
We demonstrated that HOTAIR contributes to 5FU resistance through suppressing miR-218 and activating NF-kB signaling in CRC.
Tissue resource
colorectal cancer tissues and paired noncancerous tissues
human colorectal cancer cell lines HT29
human colorectal cancer cell lines SW480
human colorectal cancer cell lines FHC
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Qilu Hospital of Shandong University
the Type Culture Collection of the Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.