Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
HOTAIR
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-34a
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HOTAIR knockdown inhibited DDP resistance of gastric cancer cells by upregulating miR-34a.
Tissue resource
gastric cancer tissues and adjacent normal tissues
human gastric cancer cell lines SGC7901
human gastric cancer cell lines MGC803
Experiment
qRT-PCR,Western blot,Dual-luciferase reporter assay
Institute
Huaihe Hospital of Henan University
Nanjing KeyGen Biotech Co., Ltd.
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.