Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
ANRIL
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
MK
Downstream target
Not available
Cancer name
Oral Squamous Cell Carcinoma
Cancer site
Lip, Oral Cavity
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CAFs in the TME contribute to the high level of MK in tumours and that CAF-derived MK can promote cisplatin resistance via the elevated expression of lncRNA ANRIL.
Tissue resource
paired oral squamous cell cancer tissues and adjacent non-tumour tissues
normal human keratinocyte cell lines HaCaT
human oral squamous cancer cell lines OSCC3
human oral squamous cancer cell lines SCC4
human oral squamous cancer cell lines HSC3
human oral squamous cancer cell linesCAL27
Experiment
qRT-PCR,Western blot
Institute
Nanjing Stomatology Hospital Affiliated to Nanjing University
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.