hsa-miR-139-5p

ncRNA information

ncRNA name

hsa-miR-139-5p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Prognosis

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Radiotherapy

Impact of wild-type ncRNA on radiotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Here we show that miR-139-5p is a potent modulator of radiotherapy response in breast cancer via its regulation of genes involved in multiple DNA repair and reactive oxygen species defense pathways.

Tissue resource

primary breast tumor specimens

Experiment

qRT-PCR,Luciferase reporter assay


Institute

the St. George Hospital

Country

Australia

Continent

Oceania