Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LINC00152
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-139-5p/NOTCH1
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
108
Male patients
64
Female patients
44
Age range and number
12(<=60)+13(>60)
PMID
Description
LINC00152 could increase the resistance of CRC cells to 5-fluorouracil (5-FU) by suppressing apoptosis.
Tissue resource
paired human colorectal cancer tissues and noncancerous tissues
human embryonic kidney cell lines HEK-293T
colorectal cancer cell lines HCT8
colorectal cancer cell lines HT29
colorectal cancer cell lines LoVo
colorectal cancer cell lines HCT116
colorectal cancer cell lines SW480
colorectal cancer cell lines SW620
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Affiliated Hospital of Jiangnan University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.