Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
MALAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
hsa-miR-101/SOX9
Cancer name
Lung Cancer
Cancer site
Lung
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
42
Male patients
27
Female patients
15
Age range and number
23(<50)+19(>=50)
PMID
Description
This MALAT1-miR-101-SOX9 feedback loop plays an important role in the chemo-resistance of lung cancer cell to DDP and may serve as a potential target for cancer treatment.
Tissue resource
paired primary lung cancer tissues and the matched adjacent normal tissues
immortalized human bronchial epithelial cell lines BEAS-2B
human lung cancer cell lines A549
human lung cancer cell lines H1299
human lung cancer cell lines HCC827
human lung cancer cell lines H358
lung cancer cisplatin-resistant cell lines A549/DDP
lung cancer cisplatin-resistant cell lines H1299/DDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Huai'an First People's Hospital
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.