Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-200b-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
c-Myc
Downstream target
PRDX2
Cancer name
Colorectal Cancer
Cancer site
Colon, Rectum, and Anus
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Our findings reveal that the c-Myc/miR-200b/PRDX2 loop regulates CRC progression and its disruption enhances tumor metastasis and chemotherapeutic resistance in CRC.
Tissue resource
colorectal cancer tissue samples and the paired normal colon mucosa tissues
human embryonic kidney cell lines HEK-293T
colorectal cancer cell lines HCT116
colorectal cancer cell lines Caco2
colorectal cancer cell lines HT29
colorectal cancer cell lines SW480
colorectal cancer cell lines LoVo
colorectal cancer cell lines SW620
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Nanchong central hospital
Shanghai Cell Bank of Type Culture Collection
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.