Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-149-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
Hippo signaling pathway
Cancer name
Ovarian Cancer
Cancer site
Ovary
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
6(<55)+14(>=55)
PMID
Description
The silencing of miR-149-5p enhanced the chemosensitivity of ovarian cancer cells to cisplatin in vitro and in vivo.
Tissue resource
ovarian cancer tissues
ovarian cancer cell lines TOV-21G
ovarian cancer cell lines A2780
ovarian cancer cell lines OVCAR-3
ovarian cancer cell lines Caov-3
ovarian cancer cell lines ES-2
ovarian cancer cell lines HO-8910
ovarian cancer cell lines SK-OV-3
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Sun Yat-sen University Cancer Center
the Shanghai Chinese Academy of Sciences cell bank
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.