Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-20a
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
LRIG1
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
Adriamycin/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We demonstrated that the miR-20a/LRIG1 regulated GC cell MDR through epidermal growth factor receptor (EGFR)-mediated PI3K/AKT and MAPK/ERK signaling pathways.
Tissue resource
paired samples of primary gastric cancer and adjacent normal tissues
human gastric cancer cell lines SGC7901
human gastric cancer multidrug-resistant cell lines SGC7901/VCR
human gastric cancer multidrug-resistant cell lines SGC7901/ADR
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Xijing Hospital
the State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.