Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
caspase-8/caspase-3
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
Trail
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
We demonstrated a CASC2/miR-24/miR-221 , which can affect the TRAIL resistance of hepatocellular carcinoma through regulating caspase 3/8.
Tissue resource
human hepatocellular carcinoma cell lines HepG2
human hepatocellular carcinoma cell lines Bel-7402
human hepatocellular carcinoma TRAIL-resistant cell lines HepG2R
human hepatocellular carcinoma TRAIL-resistant cell lines Bel-7402R
human hepatocellular carcinoma cell lines HepG2
human hepatocellular carcinoma cell lines Bel-7402
human hepatocellular carcinoma TRAIL-resistant cell lines HepG2R
human hepatocellular carcinoma TRAIL-resistant cell lines Bel-7402R
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
American Type Culture Collection
Shanghai Institute of Cell Biology
Ori-Bio Biological Technology Co., Ltd
American Type Culture Collection
Shanghai Institute of Cell Biology
Ori-Bio Biological Technology Co., Ltd
Country
USA
China
USA
China
Continent
North American
Asia
North American
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.