Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-32-5p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt signaling pathway
Cancer name
Hepatocellular Carcinoma
Cancer site
Liver
Treatment type
Chemotherapy
Drug
5-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
44
Male patients
37
Female patients
7
Age range and number
22(<50)+22(>50)
PMID
Description
Our study demonstrated that the multidrug-resistant cell, Bel/5-FU delivers miR-32-5p to sensitive cell, Bel7402 by exosomes and activates the PI3K/Akt pathway to further induce multidrug resistance by modulating angiogenesis and EMT
Tissue resource
hepatocellular carcinoma tissues and un-paired para-carcinoma liver tissues
sensitive cell lines Bel7402
resistant 5-FU resistant cell lines Bel/5-FU
hepatocellular carcinoma cell lines SMCC-7721
hepatocellular carcinoma cell lines HepG2
hepatocellular carcinoma cell lines Hep3B
human embryonic kidney cell lines HEK-293T
hepatocellular carcinoma cell lines MHCC97H
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Xi'an Jiaotong University
Key GENE Biotech
the Institute of Biochemistry and Cell Biology
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.