Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
TUSC7
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
miR-224
Cancer name
Esophageal Squamous Cell Carcinoma
Cancer site
Esophagus
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Adriamycin/Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
62
Male patients
43
Female patients
19
Age range and number
22(<=60)+40(>60)
PMID
Description
These findings suggested TUSC7 suppressed chemotherapy resistance of ESCC by downregulating miR-224 to modulate DESC1/EGFR/AKT pathway.
Tissue resource
esophageal squamous cell carcinoma tissues and their paired adjacent normal esophageal epithelial tissues
esophageal squamous cell carcinoma cell lines TE-13
esophageal squamous cell carcinoma cell lines KYSE140
esophageal squamous cell carcinoma cell lines EC9706
esophageal squamous cell carcinoma cell lines KYSE30
human esophageal epithelial cell lines Het-1A
Experiment
qRT-PCR,Western blot
Institute
the First Affiliated Hospital of Zhengzhou University
Cell Bank of Type Culture Collection of Chinese Academy of Sciences
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.