Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-17-5p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
p21
Cancer name
Gastric Cancer
Cancer site
Stomach
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Adriamycin/Cisplatin/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Downregulation of microRNA-17-5p inhibits drug resistance of gastric cancer cells partially through targeting p21.
Tissue resource
human gastric adenocarcinoma cell lines SGC7901
human gastric adenocarcinoma cisplatin-resistant cell lines SGC7901/DDP
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
Nanjing KeyGen Biotech Co., Ltd
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.