Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-19b-3p
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
PI3K/Akt signaling pathway
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Saracatinib
Impact of wild-type ncRNA on chemotherapy resistance
Down
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MiR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinibresistance by regulating PI3K/Akt pathway.
Tissue resource
breast cancer cell lines MDA-MB-231
breast cancer cell lines SK-BR-3
breast cancer cell lines BT-474
breast cancer cell lines MCF-7
Experiment
qRT-PCR,Western blot,Luciferase reporter assay
Institute
the Chinese Academy of Science Committee Type Culture Collection Cell Bank
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.