hsa-miR-19b-3p

ncRNA information

ncRNA name

hsa-miR-19b-3p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PI3K/Akt signaling pathway

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Saracatinib

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinibresistance by regulating PI3K/Akt pathway.

Tissue resource

breast cancer cell lines MDA-MB-231

breast cancer cell lines SK-BR-3

breast cancer cell lines BT-474

breast cancer cell lines MCF-7

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the Chinese Academy of Science Committee Type Culture Collection Cell Bank

Country

China

Continent

Asia