Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-202
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
HK2
Cancer name
Chronic Myeloid Leukemia
Cancer site
Leukemia
Treatment type
Chemotherapy
Drug
Imatinib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
15
Male patients
8
Female patients
7
Age range and number
Not available
PMID
Description
Overexpression of miR-202 resensitizes imatinib resistant chronic myeloid leukemia cells through targetting Hexokinase 2.
Tissue resource
blood samples from healthy volunteers and chronic myeloid leukemia patients
human chronic myeloid leukemia cell lines K562
human chronic myeloid leukemia cell lines KU812
Experiment
RT-PCR,Western blot
Institute
the Affiliated Cancer Hospital and Institute of Guangzhou Medical University
American Type Culture Collection
Country
China
USA
Continent
Asia
North American
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.